A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Most gene therapy clinical trials that systemically administered adeno-associated virus (AAV) vector enrolled only patients without anti-AAV-neutralizing antibodies. However, laboratory tests to measure neutralizing antibodies varied among clinical trials and have not been standardized. In this stud...

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Detalles Bibliográficos
Autores principales: Baatartsogt, Nemekhbayar, Kashiwakura, Yuji, Hayakawa, Morisada, Kamoshita, Nobuhiko, Hiramoto, Takafumi, Mizukami, Hiroaki, Ohmori, Tsukasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397836/
https://www.ncbi.nlm.nih.gov/pubmed/34485602
http://dx.doi.org/10.1016/j.omtm.2021.06.004

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