Directed evolution of AAV accounting for long-term and enhanced transduction of cardiovascular endothelial cells in vivo

Cardiac endothelial cells (ECs) are important targets for cardiovascular gene therapy. However, the approach of stably transducing ECs in vivo using different vectors, including adeno-associated virus (AAV), remains unexamined. Regarding this unmet need, two AAV libraries from DNA shuffling and rand...

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Detalles Bibliográficos
Autores principales: Liu, Y.B., Xu, B.C., Chen, Y.T., Yuan, X., Liu, J.Y., Liu, T., Du, G.Z., Jiang, W., Yang, Y., Zhu, Y., Chen, L.J., Ding, B.S., Wei, Y.Q., Yang, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397840/
https://www.ncbi.nlm.nih.gov/pubmed/34485601
http://dx.doi.org/10.1016/j.omtm.2021.05.015

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