Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

BACKGROUND: SARS-CoV-2 binds to membrane-bound angiotensin-converting enzyme 2 (ACE2) which may result in downregulation of membrane-bound ACE2. ACE2 is a key regulator of the renin-angiotensin system (RAS) and is responsible for degrading angiotensin II and thereby counteracting its pro-inflammator...

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Detalles Bibliográficos
Autores principales: Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, Jardine, Meg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397850/
https://www.ncbi.nlm.nih.gov/pubmed/34454580
http://dx.doi.org/10.1186/s13063-021-05521-0

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