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Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, conside...

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Autores principales: Benameur, Tarek, Soleti, Raffaella, Panaro, Maria Antonietta, La Torre, Maria Ester, Monda, Vincenzo, Messina, Giovanni, Porro, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398038/
https://www.ncbi.nlm.nih.gov/pubmed/34443381
http://dx.doi.org/10.3390/molecules26164794
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author Benameur, Tarek
Soleti, Raffaella
Panaro, Maria Antonietta
La Torre, Maria Ester
Monda, Vincenzo
Messina, Giovanni
Porro, Chiara
author_facet Benameur, Tarek
Soleti, Raffaella
Panaro, Maria Antonietta
La Torre, Maria Ester
Monda, Vincenzo
Messina, Giovanni
Porro, Chiara
author_sort Benameur, Tarek
collection PubMed
description The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed.
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spelling pubmed-83980382021-08-29 Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain Benameur, Tarek Soleti, Raffaella Panaro, Maria Antonietta La Torre, Maria Ester Monda, Vincenzo Messina, Giovanni Porro, Chiara Molecules Review The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed. MDPI 2021-08-07 /pmc/articles/PMC8398038/ /pubmed/34443381 http://dx.doi.org/10.3390/molecules26164794 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benameur, Tarek
Soleti, Raffaella
Panaro, Maria Antonietta
La Torre, Maria Ester
Monda, Vincenzo
Messina, Giovanni
Porro, Chiara
Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title_full Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title_fullStr Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title_full_unstemmed Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title_short Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
title_sort curcumin as prospective anti-aging natural compound: focus on brain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398038/
https://www.ncbi.nlm.nih.gov/pubmed/34443381
http://dx.doi.org/10.3390/molecules26164794
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