Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids

We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of mate...

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Detalles Bibliográficos
Autores principales: Dai, Ziwen, Li, Juan, Lin, Yongfang, Wang, Zhigang, Huang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398070/
https://www.ncbi.nlm.nih.gov/pubmed/34443796
http://dx.doi.org/10.3390/nano11081967
Descripción
Sumario:We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease.

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