Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids

We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of mate...

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Detalles Bibliográficos
Autores principales: Dai, Ziwen, Li, Juan, Lin, Yongfang, Wang, Zhigang, Huang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398070/
https://www.ncbi.nlm.nih.gov/pubmed/34443796
http://dx.doi.org/10.3390/nano11081967
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author Dai, Ziwen
Li, Juan
Lin, Yongfang
Wang, Zhigang
Huang, Yang
author_facet Dai, Ziwen
Li, Juan
Lin, Yongfang
Wang, Zhigang
Huang, Yang
author_sort Dai, Ziwen
collection PubMed
description We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease.
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spelling pubmed-83980702021-08-29 Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids Dai, Ziwen Li, Juan Lin, Yongfang Wang, Zhigang Huang, Yang Nanomaterials (Basel) Communication We designed a functional drug delivery system based solely on DNA. The whole system was built with only four DNA strands. Cyclization of DNA strands excluded the formation of byproducts. DNA aptamers were equipped to endow triangular DNA nanostructures with targeting ability. The homogeneity of materials enabled not only facile construction but also convenient loading of nucleic acid-based drugs with much ease. MDPI 2021-07-30 /pmc/articles/PMC8398070/ /pubmed/34443796 http://dx.doi.org/10.3390/nano11081967 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Dai, Ziwen
Li, Juan
Lin, Yongfang
Wang, Zhigang
Huang, Yang
Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title_full Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title_fullStr Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title_full_unstemmed Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title_short Facile Construction of a Solely-DNA-Based System for Targeted Delivery of Nucleic Acids
title_sort facile construction of a solely-dna-based system for targeted delivery of nucleic acids
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398070/
https://www.ncbi.nlm.nih.gov/pubmed/34443796
http://dx.doi.org/10.3390/nano11081967
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