Solvatomorphism of Moxidectin

The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatom...

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Autores principales: Grell, Toni, Barbero, Mauro, Pattarino, Franco, Giovenzana, Giovanni Battista, Colombo, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398095/
https://www.ncbi.nlm.nih.gov/pubmed/34443452
http://dx.doi.org/10.3390/molecules26164869
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author Grell, Toni
Barbero, Mauro
Pattarino, Franco
Giovenzana, Giovanni Battista
Colombo, Valentina
author_facet Grell, Toni
Barbero, Mauro
Pattarino, Franco
Giovenzana, Giovanni Battista
Colombo, Valentina
author_sort Grell, Toni
collection PubMed
description The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.
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spelling pubmed-83980952021-08-29 Solvatomorphism of Moxidectin Grell, Toni Barbero, Mauro Pattarino, Franco Giovenzana, Giovanni Battista Colombo, Valentina Molecules Article The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient. MDPI 2021-08-11 /pmc/articles/PMC8398095/ /pubmed/34443452 http://dx.doi.org/10.3390/molecules26164869 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grell, Toni
Barbero, Mauro
Pattarino, Franco
Giovenzana, Giovanni Battista
Colombo, Valentina
Solvatomorphism of Moxidectin
title Solvatomorphism of Moxidectin
title_full Solvatomorphism of Moxidectin
title_fullStr Solvatomorphism of Moxidectin
title_full_unstemmed Solvatomorphism of Moxidectin
title_short Solvatomorphism of Moxidectin
title_sort solvatomorphism of moxidectin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398095/
https://www.ncbi.nlm.nih.gov/pubmed/34443452
http://dx.doi.org/10.3390/molecules26164869
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AT giovenzanagiovannibattista solvatomorphismofmoxidectin
AT colombovalentina solvatomorphismofmoxidectin

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