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Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine

While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is re...

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Autores principales: Tessier, Nolwenn, Moawad, Fatma, Amri, Nada, Brambilla, Davide, Martel, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398144/
https://www.ncbi.nlm.nih.gov/pubmed/34452161
http://dx.doi.org/10.3390/pharmaceutics13081200
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author Tessier, Nolwenn
Moawad, Fatma
Amri, Nada
Brambilla, Davide
Martel, Catherine
author_facet Tessier, Nolwenn
Moawad, Fatma
Amri, Nada
Brambilla, Davide
Martel, Catherine
author_sort Tessier, Nolwenn
collection PubMed
description While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease.
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spelling pubmed-83981442021-08-29 Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine Tessier, Nolwenn Moawad, Fatma Amri, Nada Brambilla, Davide Martel, Catherine Pharmaceutics Review While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease. MDPI 2021-08-04 /pmc/articles/PMC8398144/ /pubmed/34452161 http://dx.doi.org/10.3390/pharmaceutics13081200 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tessier, Nolwenn
Moawad, Fatma
Amri, Nada
Brambilla, Davide
Martel, Catherine
Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title_full Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title_fullStr Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title_full_unstemmed Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title_short Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
title_sort focus on the lymphatic route to optimize drug delivery in cardiovascular medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398144/
https://www.ncbi.nlm.nih.gov/pubmed/34452161
http://dx.doi.org/10.3390/pharmaceutics13081200
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