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Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine
While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398144/ https://www.ncbi.nlm.nih.gov/pubmed/34452161 http://dx.doi.org/10.3390/pharmaceutics13081200 |
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author | Tessier, Nolwenn Moawad, Fatma Amri, Nada Brambilla, Davide Martel, Catherine |
author_facet | Tessier, Nolwenn Moawad, Fatma Amri, Nada Brambilla, Davide Martel, Catherine |
author_sort | Tessier, Nolwenn |
collection | PubMed |
description | While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease. |
format | Online Article Text |
id | pubmed-8398144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83981442021-08-29 Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine Tessier, Nolwenn Moawad, Fatma Amri, Nada Brambilla, Davide Martel, Catherine Pharmaceutics Review While oral agents have been the gold standard for cardiovascular disease therapy, the new generation of treatments is switching to other administration options that offer reduced dosing frequency and more efficacy. The lymphatic network is a unidirectional and low-pressure vascular system that is responsible for the absorption of interstitial fluids, molecules, and cells from the peripheral tissue, including the skin and the intestines. Targeting the lymphatic route for drug delivery employing traditional or new technologies and drug formulations is exponentially gaining attention in the quest to avoid the hepatic first-pass effect. The present review will give an overview of the current knowledge on the involvement of the lymphatic vessels in drug delivery in the context of cardiovascular disease. MDPI 2021-08-04 /pmc/articles/PMC8398144/ /pubmed/34452161 http://dx.doi.org/10.3390/pharmaceutics13081200 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tessier, Nolwenn Moawad, Fatma Amri, Nada Brambilla, Davide Martel, Catherine Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title | Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title_full | Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title_fullStr | Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title_full_unstemmed | Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title_short | Focus on the Lymphatic Route to Optimize Drug Delivery in Cardiovascular Medicine |
title_sort | focus on the lymphatic route to optimize drug delivery in cardiovascular medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398144/ https://www.ncbi.nlm.nih.gov/pubmed/34452161 http://dx.doi.org/10.3390/pharmaceutics13081200 |
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