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First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery

Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vagin...

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Autores principales: Mesini, Alessio, Saffioti, Carolina, Mariani, Marcello, Florio, Angelo, Medici, Chiara, Moscatelli, Andrea, Castagnola, Elio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398378/
https://www.ncbi.nlm.nih.gov/pubmed/34436188
http://dx.doi.org/10.3390/jof7080649
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author Mesini, Alessio
Saffioti, Carolina
Mariani, Marcello
Florio, Angelo
Medici, Chiara
Moscatelli, Andrea
Castagnola, Elio
author_facet Mesini, Alessio
Saffioti, Carolina
Mariani, Marcello
Florio, Angelo
Medici, Chiara
Moscatelli, Andrea
Castagnola, Elio
author_sort Mesini, Alessio
collection PubMed
description Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vaginal delivery from a C. auris colonized mother, who was colonized by C. auris within a few hours after birth. We could not discriminate whether the colonization route was the birth canal or the intensive care unit environment. The infant died on her third day of life because of complications related to prematurity, without signs or symptoms of infections. In contexts with high rates of C.auris colonization, antifungal prophylaxis in low-birth-weight, preterm neonates with micafungin should be considered over fluconazole due to the C. auris resistance profile, at least until its presence is excluded.
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spelling pubmed-83983782021-08-29 First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery Mesini, Alessio Saffioti, Carolina Mariani, Marcello Florio, Angelo Medici, Chiara Moscatelli, Andrea Castagnola, Elio J Fungi (Basel) Case Report Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vaginal delivery from a C. auris colonized mother, who was colonized by C. auris within a few hours after birth. We could not discriminate whether the colonization route was the birth canal or the intensive care unit environment. The infant died on her third day of life because of complications related to prematurity, without signs or symptoms of infections. In contexts with high rates of C.auris colonization, antifungal prophylaxis in low-birth-weight, preterm neonates with micafungin should be considered over fluconazole due to the C. auris resistance profile, at least until its presence is excluded. MDPI 2021-08-10 /pmc/articles/PMC8398378/ /pubmed/34436188 http://dx.doi.org/10.3390/jof7080649 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mesini, Alessio
Saffioti, Carolina
Mariani, Marcello
Florio, Angelo
Medici, Chiara
Moscatelli, Andrea
Castagnola, Elio
First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title_full First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title_fullStr First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title_full_unstemmed First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title_short First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
title_sort first case of candida auris colonization in a preterm, extremely low-birth-weight newborn after vaginal delivery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398378/
https://www.ncbi.nlm.nih.gov/pubmed/34436188
http://dx.doi.org/10.3390/jof7080649
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