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First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery
Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vagin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398378/ https://www.ncbi.nlm.nih.gov/pubmed/34436188 http://dx.doi.org/10.3390/jof7080649 |
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author | Mesini, Alessio Saffioti, Carolina Mariani, Marcello Florio, Angelo Medici, Chiara Moscatelli, Andrea Castagnola, Elio |
author_facet | Mesini, Alessio Saffioti, Carolina Mariani, Marcello Florio, Angelo Medici, Chiara Moscatelli, Andrea Castagnola, Elio |
author_sort | Mesini, Alessio |
collection | PubMed |
description | Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vaginal delivery from a C. auris colonized mother, who was colonized by C. auris within a few hours after birth. We could not discriminate whether the colonization route was the birth canal or the intensive care unit environment. The infant died on her third day of life because of complications related to prematurity, without signs or symptoms of infections. In contexts with high rates of C.auris colonization, antifungal prophylaxis in low-birth-weight, preterm neonates with micafungin should be considered over fluconazole due to the C. auris resistance profile, at least until its presence is excluded. |
format | Online Article Text |
id | pubmed-8398378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83983782021-08-29 First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery Mesini, Alessio Saffioti, Carolina Mariani, Marcello Florio, Angelo Medici, Chiara Moscatelli, Andrea Castagnola, Elio J Fungi (Basel) Case Report Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vaginal delivery from a C. auris colonized mother, who was colonized by C. auris within a few hours after birth. We could not discriminate whether the colonization route was the birth canal or the intensive care unit environment. The infant died on her third day of life because of complications related to prematurity, without signs or symptoms of infections. In contexts with high rates of C.auris colonization, antifungal prophylaxis in low-birth-weight, preterm neonates with micafungin should be considered over fluconazole due to the C. auris resistance profile, at least until its presence is excluded. MDPI 2021-08-10 /pmc/articles/PMC8398378/ /pubmed/34436188 http://dx.doi.org/10.3390/jof7080649 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Mesini, Alessio Saffioti, Carolina Mariani, Marcello Florio, Angelo Medici, Chiara Moscatelli, Andrea Castagnola, Elio First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title | First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title_full | First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title_fullStr | First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title_full_unstemmed | First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title_short | First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery |
title_sort | first case of candida auris colonization in a preterm, extremely low-birth-weight newborn after vaginal delivery |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398378/ https://www.ncbi.nlm.nih.gov/pubmed/34436188 http://dx.doi.org/10.3390/jof7080649 |
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