Mathematical Models for FDG Kinetics in Cancer: A Review

Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issu...

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Detalles Bibliográficos
Autores principales: Sommariva, Sara, Caviglia, Giacomo, Sambuceti, Gianmario, Piana, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398381/
https://www.ncbi.nlm.nih.gov/pubmed/34436460
http://dx.doi.org/10.3390/metabo11080519
Descripción
Sumario:Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issues and on the impact of complex physiological conditions on the mathematical properties of the models.

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