Cargando…

Optimization of the Transwell(®) System for Assessing the Dissolution Behavior of Orally Inhaled Drug Products through In Vitro and In Silico Approaches

The aim of this study was to further evaluate and optimize the Transwell(®) system for assessing the dissolution behavior of orally inhaled drug products (OIDPs), using fluticasone propionate as a model drug. Sample preparation involved the collection of a relevant inhalable dose fraction through an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amini, Elham, Kurumaddali, Abhinav, Bhagwat, Sharvari, Berger, Simon M., Hochhaus, Günther
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398439/ https://www.ncbi.nlm.nih.gov/pubmed/34452069 http://dx.doi.org/10.3390/pharmaceutics13081109

Ejemplares similares

Development of an Aerosol Dose Collection Apparatus for In Vitro Dissolution Measurements of Orally Inhaled Drug Products
por: Price, Robert, et al.
Publicado: (2020)

In Vitro Dissolution and Permeability Testing of Inhalation Products: Challenges and Advances
por: Nokhodchi, Ali, et al.
Publicado: (2023)

In Vitro Dissolution and in Silico Modeling Shortcuts in Bioequivalence Testing
por: Al-Tabakha, Moawia M., et al.
Publicado: (2020)

An Improved Transwell Design for Microelectrode Ion-Flux Measurements
por: Buchroithner, Boris, et al.
Publicado: (2021)

Use of PBPK Modeling To Evaluate the Performance of DissolvIt, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products
por: Hassoun, Mireille, et al.
Publicado: (2019)

Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices
por: Frost, Timothy S., et al.
Publicado: (2019)

3D-Printed electrochemical sensor-integrated transwell systems
por: Ramiah Rajasekaran, Pradeep, et al.
Publicado: (2020)

Transwell migration assay to interrogate human CAR-T cell chemotaxis
por: Oner, Arman, et al.
Publicado: (2022)

Relative receptor affinity comparisons among inhaled/intranasal corticosteroids: perspectives on clinical relevance
por: Hochhaus, Günther
Publicado: (2008)

Dissolution and Absorption of Inhaled Drug Particles in the Lungs
por: Eedara, Basanth Babu, et al.
Publicado: (2022)

A Meta-Analysis of Higher-risk Myelodysplastic Syndrome Trials to Evaluate the Relationship between Short-term Endpoints and Overall Survival
por: Kurumaddali, Abhinav, et al.
Publicado: (2019)

Tissue-on-a-Chip: Microphysiometry With Human 3D Models on Transwell Inserts
por: Schmidt, Christian, et al.
Publicado: (2020)

A Transwell-Based Vascularized Model to Investigate the Effect of Interstitial Flow on Vasculogenesis
por: Deng, Pengwei, et al.
Publicado: (2022)

Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts
por: Chandiramohan, Abiram, et al.
Publicado: (2021)

Model for the Analysis of Membrane-Type Dissolution Tests for Inhaled Drugs
por: Frenning, Göran, et al.
Publicado: (2020)

RespiCell(TM): An Innovative Dissolution Apparatus for Inhaled Products
por: Sonvico, Fabio, et al.
Publicado: (2021)

A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication
por: Thayanithy, Venugopal, et al.
Publicado: (2017)

A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells
por: Stone, Nicole L., et al.
Publicado: (2019)

Fibroblast-like cells change gene expression of bone remodelling markers in transwell cultures
por: Hartmann, Eliza S., et al.
Publicado: (2020)

TEER and Ion Selective Transwell-Integrated Sensors System for Caco-2 Cell Model
por: Sciurti, Elisa, et al.
Publicado: (2023)

Quantitative Analysis of a Pilot Transwell Barrier Model with Automated Sampling and Mathematical Modeling
por: Tárnoki-Zách, Júlia, et al.
Publicado: (2023)

Gene Expression Changes in Long-Term In Vitro Human Blood-Brain Barrier Models and Their Dependence on a Transwell Scaffold Material
por: Gaston, Joel D., et al.
Publicado: (2017)

Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model
por: Merolle, Matilde, et al.
Publicado: (2020)

Isolation, culture, and cryosectioning of primary porcine retinal pigment epithelium on transwell cell culture inserts
por: Hood, Erika M.S., et al.
Publicado: (2022)

Development of Abiraterone Acetate Nanocrystal Tablets to Enhance Oral Bioavailability: Formulation Optimization, Characterization, In Vitro Dissolution and Pharmacokinetic Evaluation
por: Liu, Yuanfen, et al.
Publicado: (2022)

Comparative Assessment of In Vitro and In Silico Methods for Aerodynamic Characterization of Powders for Inhalation
por: Ignjatović, Jelisaveta, et al.
Publicado: (2021)

The Effect of Platelet Rich Plasma on Chondrogenic Differentiation of Human Adipose Derived Stem Cells in Transwell Culture
por: Mardani, Mohammad, et al.
Publicado: (2013)

Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model
por: Bluhmki, Teresa, et al.
Publicado: (2020)

Protocol to quantify enzymatic effects on vitreous liquefaction in porcine eyes using a transwell-plate system
por: Wolf, Julian, et al.
Publicado: (2022)

Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery
por: Wang, Ke, et al.
Publicado: (2023)

Mechanistic modeling of generic orally inhaled drug products: A workshop summary report
por: Walenga, Ross L., et al.
Publicado: (2022)

Comparison of LPS-stimulated release of cytokines in punch versus transwell tissue culture systems of human gestational membranes
por: Miller, Mark F, et al.
Publicado: (2010)

I-AbACUS: a Reliable Software Tool for the Semi-Automatic Analysis of Invasion and Migration Transwell Assays
por: Cortesi, Marilisa, et al.
Publicado: (2018)

Comparative Analysis of Inflammatory Cytokine Release and Alveolar Epithelial Barrier Invasion in a Transwell(®) Bilayer Model of Mucormycosis
por: Belic, Stanislav, et al.
Publicado: (2019)

Role of peptide transporters in small peptide uptake of bovine mammary epithelial cells cultured in a transwell chamber
por: Zhou, Miaomiao, et al.
Publicado: (2023)

Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation
por: Fouad, Shahinaze A., et al.
Publicado: (2020)

In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products
por: Walenga, Ross L., et al.
Publicado: (2019)

Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model
por: van der Zwaan, Irès, et al.
Publicado: (2022)

Toxicological Assessment of Inhaled Nanoparticles: Role of in Vivo, ex Vivo, in Vitro, and in Silico Studies
por: Fröhlich, Eleonore, et al.
Publicado: (2014)

Formulation and In Vitro and In Silico Characterization of “Nano-in-Micro” Dry Powder Inhalers Containing Meloxicam
por: Party, Petra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ui8inq8ehsd643krj1v134o5vd