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Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network

The functional connectivity (FC) patterns of resting-state functional magnetic resonance imaging (rs-fMRI) play an essential role in the development of autism spectrum disorders (ASD) classification models. There are available methods in literature that have used FC patterns as inputs for binary cla...

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Autores principales: Al-Hiyali, Mohammed Isam, Yahya, Norashikin, Faye, Ibrahima, Hussein, Ahmed Faeq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398492/
https://www.ncbi.nlm.nih.gov/pubmed/34450699
http://dx.doi.org/10.3390/s21165256
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author Al-Hiyali, Mohammed Isam
Yahya, Norashikin
Faye, Ibrahima
Hussein, Ahmed Faeq
author_facet Al-Hiyali, Mohammed Isam
Yahya, Norashikin
Faye, Ibrahima
Hussein, Ahmed Faeq
author_sort Al-Hiyali, Mohammed Isam
collection PubMed
description The functional connectivity (FC) patterns of resting-state functional magnetic resonance imaging (rs-fMRI) play an essential role in the development of autism spectrum disorders (ASD) classification models. There are available methods in literature that have used FC patterns as inputs for binary classification models, but the results barely reach an accuracy of 80%. Additionally, the generalizability across multiple sites of the models has not been investigated. Due to the lack of ASD subtypes identification model, the multi-class classification is proposed in the present study. This study aims to develop automated identification of autism spectrum disorder (ASD) subtypes using convolutional neural networks (CNN) using dynamic FC as its inputs. The rs-fMRI dataset used in this study consists of 144 individuals from 8 independent sites, labeled based on three ASD subtypes, namely autistic disorder (ASD), Asperger’s disorder (APD), and pervasive developmental disorder not otherwise specified (PDD-NOS). The blood-oxygen-level-dependent (BOLD) signals from 116 brain nodes of automated anatomical labeling (AAL) atlas are used, where the top-ranked node is determined based on one-way analysis of variance (ANOVA) of the power spectral density (PSD) values. Based on the statistical analysis of the PSD values of 3-level ASD and normal control (NC), putamen_R is obtained as the top-ranked node and used for the wavelet coherence computation. With good resolution in time and frequency domain, scalograms of wavelet coherence between the top-ranked node and the rest of the nodes are used as dynamic FC feature input to the convolutional neural networks (CNN). The dynamic FC patterns of wavelet coherence scalogram represent phase synchronization between the pairs of BOLD signals. Classification algorithms are developed using CNN and the wavelet coherence scalograms for binary and multi-class identification were trained and tested using cross-validation and leave-one-out techniques. Results of binary classification (ASD vs. NC) and multi-class classification (ASD vs. APD vs. PDD-NOS vs. NC) yielded, respectively, 89.8% accuracy and 82.1% macro-average accuracy, respectively. Findings from this study have illustrated the good potential of wavelet coherence technique in representing dynamic FC between brain nodes and open possibilities for its application in computer aided diagnosis of other neuropsychiatric disorders, such as depression or schizophrenia.
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spelling pubmed-83984922021-08-29 Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network Al-Hiyali, Mohammed Isam Yahya, Norashikin Faye, Ibrahima Hussein, Ahmed Faeq Sensors (Basel) Article The functional connectivity (FC) patterns of resting-state functional magnetic resonance imaging (rs-fMRI) play an essential role in the development of autism spectrum disorders (ASD) classification models. There are available methods in literature that have used FC patterns as inputs for binary classification models, but the results barely reach an accuracy of 80%. Additionally, the generalizability across multiple sites of the models has not been investigated. Due to the lack of ASD subtypes identification model, the multi-class classification is proposed in the present study. This study aims to develop automated identification of autism spectrum disorder (ASD) subtypes using convolutional neural networks (CNN) using dynamic FC as its inputs. The rs-fMRI dataset used in this study consists of 144 individuals from 8 independent sites, labeled based on three ASD subtypes, namely autistic disorder (ASD), Asperger’s disorder (APD), and pervasive developmental disorder not otherwise specified (PDD-NOS). The blood-oxygen-level-dependent (BOLD) signals from 116 brain nodes of automated anatomical labeling (AAL) atlas are used, where the top-ranked node is determined based on one-way analysis of variance (ANOVA) of the power spectral density (PSD) values. Based on the statistical analysis of the PSD values of 3-level ASD and normal control (NC), putamen_R is obtained as the top-ranked node and used for the wavelet coherence computation. With good resolution in time and frequency domain, scalograms of wavelet coherence between the top-ranked node and the rest of the nodes are used as dynamic FC feature input to the convolutional neural networks (CNN). The dynamic FC patterns of wavelet coherence scalogram represent phase synchronization between the pairs of BOLD signals. Classification algorithms are developed using CNN and the wavelet coherence scalograms for binary and multi-class identification were trained and tested using cross-validation and leave-one-out techniques. Results of binary classification (ASD vs. NC) and multi-class classification (ASD vs. APD vs. PDD-NOS vs. NC) yielded, respectively, 89.8% accuracy and 82.1% macro-average accuracy, respectively. Findings from this study have illustrated the good potential of wavelet coherence technique in representing dynamic FC between brain nodes and open possibilities for its application in computer aided diagnosis of other neuropsychiatric disorders, such as depression or schizophrenia. MDPI 2021-08-04 /pmc/articles/PMC8398492/ /pubmed/34450699 http://dx.doi.org/10.3390/s21165256 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Hiyali, Mohammed Isam
Yahya, Norashikin
Faye, Ibrahima
Hussein, Ahmed Faeq
Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title_full Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title_fullStr Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title_full_unstemmed Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title_short Identification of Autism Subtypes Based on Wavelet Coherence of BOLD FMRI Signals Using Convolutional Neural Network
title_sort identification of autism subtypes based on wavelet coherence of bold fmri signals using convolutional neural network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398492/
https://www.ncbi.nlm.nih.gov/pubmed/34450699
http://dx.doi.org/10.3390/s21165256
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