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Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar

Despite a significant decline in the incidence of malaria in Myanmar recently, malaria is still an important public health concern in the country. Although Plasmodium falciparum is associated with the highest incidence of malaria in Myanmar, the proportion of P. vivax cases has shown a gradual incre...

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Autores principales: Naw, Haung, Kang, Jung-Mi, Moe, Mya, Lee, Jinyoung, Lê, Hương Giang, Võ, Tuấn Cường, Mya, Yi Yi, Myint, Moe Kyaw, Htun, Zaw Than, Kim, Tong-Soo, Shin, Ho-Joon, Na, Byoung-Kuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398579/
https://www.ncbi.nlm.nih.gov/pubmed/34451379
http://dx.doi.org/10.3390/pathogens10080916
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author Naw, Haung
Kang, Jung-Mi
Moe, Mya
Lee, Jinyoung
Lê, Hương Giang
Võ, Tuấn Cường
Mya, Yi Yi
Myint, Moe Kyaw
Htun, Zaw Than
Kim, Tong-Soo
Shin, Ho-Joon
Na, Byoung-Kuk
author_facet Naw, Haung
Kang, Jung-Mi
Moe, Mya
Lee, Jinyoung
Lê, Hương Giang
Võ, Tuấn Cường
Mya, Yi Yi
Myint, Moe Kyaw
Htun, Zaw Than
Kim, Tong-Soo
Shin, Ho-Joon
Na, Byoung-Kuk
author_sort Naw, Haung
collection PubMed
description Despite a significant decline in the incidence of malaria in Myanmar recently, malaria is still an important public health concern in the country. Although Plasmodium falciparum is associated with the highest incidence of malaria in Myanmar, the proportion of P. vivax cases has shown a gradual increase in recent years. The genetic diversity of P. vivax merozoite surface protein-1 block 5-6 (pvmsp-1 ICB 5-6) in the P. vivax population of Myanmar was analyzed to obtain a comprehensive insight into its genetic heterogeneity and evolutionary history. High levels of genetic diversity of pvmsp-1 ICB 5-6 were identified in the P. vivax isolates collected from Myanmar between 2013 and 2015. Thirty-nine distinct haplotypes of pvmsp-1 ICB 5-6 (13 for Sal I type, 20 for recombinant type, and 6 for Belem type) were found at the amino acid level. Comparative analyses of the genetic diversity of pvmsp-1 ICB 5-6 sequences in the recent (2013–2015) and the past (2004) P. vivax populations in Myanmar revealed genetic expansion of the pvmsp-1 ICB 5-6 in recent years, albeit with a declined incidence. The recent increase in the genetic heterogeneity of Myanmar pvmsp-1 ICB 5-6 is attributed to a combination of factors, including accumulated mutations and recombination. These results suggest that the size of the P. vivax population in Myanmar is sufficient to enable the generation and maintenance of genetic diversity, warranting continuous molecular surveillance of genetic variation in Myanmar P. vivax.
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spelling pubmed-83985792021-08-29 Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar Naw, Haung Kang, Jung-Mi Moe, Mya Lee, Jinyoung Lê, Hương Giang Võ, Tuấn Cường Mya, Yi Yi Myint, Moe Kyaw Htun, Zaw Than Kim, Tong-Soo Shin, Ho-Joon Na, Byoung-Kuk Pathogens Article Despite a significant decline in the incidence of malaria in Myanmar recently, malaria is still an important public health concern in the country. Although Plasmodium falciparum is associated with the highest incidence of malaria in Myanmar, the proportion of P. vivax cases has shown a gradual increase in recent years. The genetic diversity of P. vivax merozoite surface protein-1 block 5-6 (pvmsp-1 ICB 5-6) in the P. vivax population of Myanmar was analyzed to obtain a comprehensive insight into its genetic heterogeneity and evolutionary history. High levels of genetic diversity of pvmsp-1 ICB 5-6 were identified in the P. vivax isolates collected from Myanmar between 2013 and 2015. Thirty-nine distinct haplotypes of pvmsp-1 ICB 5-6 (13 for Sal I type, 20 for recombinant type, and 6 for Belem type) were found at the amino acid level. Comparative analyses of the genetic diversity of pvmsp-1 ICB 5-6 sequences in the recent (2013–2015) and the past (2004) P. vivax populations in Myanmar revealed genetic expansion of the pvmsp-1 ICB 5-6 in recent years, albeit with a declined incidence. The recent increase in the genetic heterogeneity of Myanmar pvmsp-1 ICB 5-6 is attributed to a combination of factors, including accumulated mutations and recombination. These results suggest that the size of the P. vivax population in Myanmar is sufficient to enable the generation and maintenance of genetic diversity, warranting continuous molecular surveillance of genetic variation in Myanmar P. vivax. MDPI 2021-07-21 /pmc/articles/PMC8398579/ /pubmed/34451379 http://dx.doi.org/10.3390/pathogens10080916 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naw, Haung
Kang, Jung-Mi
Moe, Mya
Lee, Jinyoung
Lê, Hương Giang
Võ, Tuấn Cường
Mya, Yi Yi
Myint, Moe Kyaw
Htun, Zaw Than
Kim, Tong-Soo
Shin, Ho-Joon
Na, Byoung-Kuk
Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title_full Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title_fullStr Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title_full_unstemmed Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title_short Temporal Changes in the Genetic Diversity of Plasmodium vivax Merozoite Surface Protein-1 in Myanmar
title_sort temporal changes in the genetic diversity of plasmodium vivax merozoite surface protein-1 in myanmar
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398579/
https://www.ncbi.nlm.nih.gov/pubmed/34451379
http://dx.doi.org/10.3390/pathogens10080916
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