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Pharmacokinetics and Toxicity Evaluation of a PLGA and Chitosan-Based Micro-Implant for Sustained Release of Methotrexate in Rabbit Vitreous

The present research investigates the pharmacokinetics and toxicity of a chitosan (CS) and poly(lactic-co-glycolic) acid (PLGA)-based methotrexate (MTX) intravitreal micro-implant in normal rabbit eyes. PLGA and CS-based micro-implants containing 400 µg of MTX were surgically inserted in the vitreou...

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Detalles Bibliográficos
Autores principales:	Manna, Soumyarwit, Donnell, Anna M., Faraj, Rafaela Q. Caixeta, Riemann, Blanca I., Riemann, Christopher D., Augsburger, James J., Correa, Zelia M., Banerjee, Rupak K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398642/ https://www.ncbi.nlm.nih.gov/pubmed/34452188 http://dx.doi.org/10.3390/pharmaceutics13081227

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