Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 Infection

HLA transgenic mice are instrumental for evaluation of human-specific immune responses to viral infection. Mice do not develop COVID-19 upon infection with SARS-CoV-2 due to the strict tropism of the virus to the human ACE2 receptor. The aim of the current study was the implementation of an adenovir...

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Detalles Bibliográficos
Autores principales: Chitlaru, Theodor, Bar-Haim, Erez, Bar-On, Liat, Rotem, Shahar, Cohen, Hila, Elia, Uri, Gur, David, Aftalion, Moshe, Alkalay, Ron, Makdasi, Efi, Evgy, Yentl, Falach, Reut, Israeli, Ma’ayan, Bercovich-Kinori, Adi, Achdout, Hagit, Yahalom-Ronen, Yfat, Rosenfeld, Ronit, Cohen, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398702/
https://www.ncbi.nlm.nih.gov/pubmed/34451403
http://dx.doi.org/10.3390/pathogens10080940

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