Cargando…
The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms
Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398709/ https://www.ncbi.nlm.nih.gov/pubmed/34441019 http://dx.doi.org/10.3390/medicina57080813 |
_version_ | 1783744904095072256 |
---|---|
author | Lanzarone, Giuseppe Olivi, Matteo |
author_facet | Lanzarone, Giuseppe Olivi, Matteo |
author_sort | Lanzarone, Giuseppe |
collection | PubMed |
description | Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. Cytogenetics has a well-established prognostic role in acute leukemias and in myelodysplastic syndromes, where it drives the clinical decisions. NGS techniques can find adverse mutations with clear prognostic value and are currently included in the prognostic evaluation of MPNs in scores such as MIPSS, GIPSS, MIPSS-PV, and MIPSS-ET. We suggest that cytogenetics (considering its availability and relative cost) has a role regarding prognostic and therapeutic decisions. |
format | Online Article Text |
id | pubmed-8398709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83987092021-08-29 The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms Lanzarone, Giuseppe Olivi, Matteo Medicina (Kaunas) Review Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. Cytogenetics has a well-established prognostic role in acute leukemias and in myelodysplastic syndromes, where it drives the clinical decisions. NGS techniques can find adverse mutations with clear prognostic value and are currently included in the prognostic evaluation of MPNs in scores such as MIPSS, GIPSS, MIPSS-PV, and MIPSS-ET. We suggest that cytogenetics (considering its availability and relative cost) has a role regarding prognostic and therapeutic decisions. MDPI 2021-08-09 /pmc/articles/PMC8398709/ /pubmed/34441019 http://dx.doi.org/10.3390/medicina57080813 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lanzarone, Giuseppe Olivi, Matteo The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title_full | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title_fullStr | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title_full_unstemmed | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title_short | The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms |
title_sort | prognostic role of cytogenetics analysis in philadelphia negative myeloproliferative neoplasms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398709/ https://www.ncbi.nlm.nih.gov/pubmed/34441019 http://dx.doi.org/10.3390/medicina57080813 |
work_keys_str_mv | AT lanzaronegiuseppe theprognosticroleofcytogeneticsanalysisinphiladelphianegativemyeloproliferativeneoplasms AT olivimatteo theprognosticroleofcytogeneticsanalysisinphiladelphianegativemyeloproliferativeneoplasms AT lanzaronegiuseppe prognosticroleofcytogeneticsanalysisinphiladelphianegativemyeloproliferativeneoplasms AT olivimatteo prognosticroleofcytogeneticsanalysisinphiladelphianegativemyeloproliferativeneoplasms |