Cargando…

Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients

Psoriasis has been associated with increased frequency of hepatic diseases. Psoriasis severity, obesity, insulin resistance, aspartate aminotransferase level, platelet count, and alcohol use are significant predictors for advanced fibrosis in psoriasis patients. Although psoriasis patients also pres...

Descripción completa

Detalles Bibliográficos
Autores principales: Brunner, Kinga, Oláh, Péter, Moezzi, Mehdi, Pár, Gabriella, Vincze, Áron, Breitenbach, Zita, Gyulai, Rolland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398768/
https://www.ncbi.nlm.nih.gov/pubmed/34440507
http://dx.doi.org/10.3390/life11080763
_version_ 1783744917533622272
author Brunner, Kinga
Oláh, Péter
Moezzi, Mehdi
Pár, Gabriella
Vincze, Áron
Breitenbach, Zita
Gyulai, Rolland
author_facet Brunner, Kinga
Oláh, Péter
Moezzi, Mehdi
Pár, Gabriella
Vincze, Áron
Breitenbach, Zita
Gyulai, Rolland
author_sort Brunner, Kinga
collection PubMed
description Psoriasis has been associated with increased frequency of hepatic diseases. Psoriasis severity, obesity, insulin resistance, aspartate aminotransferase level, platelet count, and alcohol use are significant predictors for advanced fibrosis in psoriasis patients. Although psoriasis patients also present body composition changes (e.g., higher overall body fat, visceral fat and sarcopenia), and these have recently been reported as risk factors for hepatic fibrosis, to date, body composition has not been prospectively investigated in psoriasis in the context of liver fibrosis. In this study anthropometric assessment (body weight and body mass index (BMI)), body composition analysis (body fat%, visceral fat scores and muscle mass%), and liver stiffness measurements (using transient elastography [TE]) were done in 52 psoriasis patients undergoing methotrexate therapy. Fourteen patients (26.9%) had advanced (F3–F4) liver fibrosis. There was no correlation between the patients’ liver stiffness values and the cumulative MTX doses. On the other hand, patients with higher BMI values, total body fat% and visceral fat scores were significantly more likely to present with higher hepatic stiffness values. BMI was a significant predictor of hepatic fibrosis in both genders. In males, body fat% (R = 0.578, p = 0.002) and, especially, visceral fat scores (R = 0.716, p < 0.001) had statistically significant correlation with stiffness scores, while in females only visceral fat scores were statistically significant predictors of the liver stiffness values (R = 0.452, p = 0.023), and body fat% was not (R = 0.187, p = 0.382). Our results suggest that anthropometric data should be assessed differently in female and male psoriasis patients when evaluating liver fibrosis risk.
format Online
Article
Text
id pubmed-8398768
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83987682021-08-29 Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients Brunner, Kinga Oláh, Péter Moezzi, Mehdi Pár, Gabriella Vincze, Áron Breitenbach, Zita Gyulai, Rolland Life (Basel) Article Psoriasis has been associated with increased frequency of hepatic diseases. Psoriasis severity, obesity, insulin resistance, aspartate aminotransferase level, platelet count, and alcohol use are significant predictors for advanced fibrosis in psoriasis patients. Although psoriasis patients also present body composition changes (e.g., higher overall body fat, visceral fat and sarcopenia), and these have recently been reported as risk factors for hepatic fibrosis, to date, body composition has not been prospectively investigated in psoriasis in the context of liver fibrosis. In this study anthropometric assessment (body weight and body mass index (BMI)), body composition analysis (body fat%, visceral fat scores and muscle mass%), and liver stiffness measurements (using transient elastography [TE]) were done in 52 psoriasis patients undergoing methotrexate therapy. Fourteen patients (26.9%) had advanced (F3–F4) liver fibrosis. There was no correlation between the patients’ liver stiffness values and the cumulative MTX doses. On the other hand, patients with higher BMI values, total body fat% and visceral fat scores were significantly more likely to present with higher hepatic stiffness values. BMI was a significant predictor of hepatic fibrosis in both genders. In males, body fat% (R = 0.578, p = 0.002) and, especially, visceral fat scores (R = 0.716, p < 0.001) had statistically significant correlation with stiffness scores, while in females only visceral fat scores were statistically significant predictors of the liver stiffness values (R = 0.452, p = 0.023), and body fat% was not (R = 0.187, p = 0.382). Our results suggest that anthropometric data should be assessed differently in female and male psoriasis patients when evaluating liver fibrosis risk. MDPI 2021-07-29 /pmc/articles/PMC8398768/ /pubmed/34440507 http://dx.doi.org/10.3390/life11080763 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brunner, Kinga
Oláh, Péter
Moezzi, Mehdi
Pár, Gabriella
Vincze, Áron
Breitenbach, Zita
Gyulai, Rolland
Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title_full Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title_fullStr Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title_full_unstemmed Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title_short Association of Nonalcoholic Hepatic Fibrosis with Body Composition in Female and Male Psoriasis Patients
title_sort association of nonalcoholic hepatic fibrosis with body composition in female and male psoriasis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398768/
https://www.ncbi.nlm.nih.gov/pubmed/34440507
http://dx.doi.org/10.3390/life11080763
work_keys_str_mv AT brunnerkinga associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT olahpeter associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT moezzimehdi associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT pargabriella associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT vinczearon associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT breitenbachzita associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients
AT gyulairolland associationofnonalcoholichepaticfibrosiswithbodycompositioninfemaleandmalepsoriasispatients