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Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398861/ https://www.ncbi.nlm.nih.gov/pubmed/34451848 http://dx.doi.org/10.3390/ph14080751 |
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author | Srivastava, Swayam Prakash Srivastava, Rohit Chand, Subhash Goodwin, Julie E. |
author_facet | Srivastava, Swayam Prakash Srivastava, Rohit Chand, Subhash Goodwin, Julie E. |
author_sort | Srivastava, Swayam Prakash |
collection | PubMed |
description | The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence neighboring cell homeostasis, resulting in severe proteinuria and organ fibrosis in diabetes. Altered microRNA expression disrupts cellular homeostasis and the renin-angiotensin-system, targets reno-protective signaling proteins, such as angiotensin-converting enzyme 2 (ACE2) and MAS1 receptor (MAS), and facilitates viral entry and replication in kidney cells. COVID-19-associated endotheliopathy that interacts with other cell types, such as neutrophils, platelets, and macrophages, is one factor that accelerates prethrombotic reactions and thrombus formation, resulting in organ failures in diabetes. Apart from targeting vital signaling through ACE2 and MAS, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are also associated with higher profibrotic dipeptidyl transferase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK) activation in kidney cells. Lowered DPP-4 levels and restoration of AMPK levels are organ-protective, suggesting a pathogenic role of DPP-4 and a protective role of AMPK in diabetic COVID-19 patients. In addition to standard care provided to COVID-19 patients, we urgently need novel drug therapies that support the stability and function of both organs and cell types in diabetes. |
format | Online Article Text |
id | pubmed-8398861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83988612021-08-29 Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease Srivastava, Swayam Prakash Srivastava, Rohit Chand, Subhash Goodwin, Julie E. Pharmaceuticals (Basel) Review The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence neighboring cell homeostasis, resulting in severe proteinuria and organ fibrosis in diabetes. Altered microRNA expression disrupts cellular homeostasis and the renin-angiotensin-system, targets reno-protective signaling proteins, such as angiotensin-converting enzyme 2 (ACE2) and MAS1 receptor (MAS), and facilitates viral entry and replication in kidney cells. COVID-19-associated endotheliopathy that interacts with other cell types, such as neutrophils, platelets, and macrophages, is one factor that accelerates prethrombotic reactions and thrombus formation, resulting in organ failures in diabetes. Apart from targeting vital signaling through ACE2 and MAS, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are also associated with higher profibrotic dipeptidyl transferase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK) activation in kidney cells. Lowered DPP-4 levels and restoration of AMPK levels are organ-protective, suggesting a pathogenic role of DPP-4 and a protective role of AMPK in diabetic COVID-19 patients. In addition to standard care provided to COVID-19 patients, we urgently need novel drug therapies that support the stability and function of both organs and cell types in diabetes. MDPI 2021-07-30 /pmc/articles/PMC8398861/ /pubmed/34451848 http://dx.doi.org/10.3390/ph14080751 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Srivastava, Swayam Prakash Srivastava, Rohit Chand, Subhash Goodwin, Julie E. Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title | Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title_full | Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title_fullStr | Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title_full_unstemmed | Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title_short | Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease |
title_sort | coronavirus disease (covid)-19 and diabetic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398861/ https://www.ncbi.nlm.nih.gov/pubmed/34451848 http://dx.doi.org/10.3390/ph14080751 |
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