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Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease

The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence...

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Autores principales: Srivastava, Swayam Prakash, Srivastava, Rohit, Chand, Subhash, Goodwin, Julie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398861/
https://www.ncbi.nlm.nih.gov/pubmed/34451848
http://dx.doi.org/10.3390/ph14080751
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author Srivastava, Swayam Prakash
Srivastava, Rohit
Chand, Subhash
Goodwin, Julie E.
author_facet Srivastava, Swayam Prakash
Srivastava, Rohit
Chand, Subhash
Goodwin, Julie E.
author_sort Srivastava, Swayam Prakash
collection PubMed
description The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence neighboring cell homeostasis, resulting in severe proteinuria and organ fibrosis in diabetes. Altered microRNA expression disrupts cellular homeostasis and the renin-angiotensin-system, targets reno-protective signaling proteins, such as angiotensin-converting enzyme 2 (ACE2) and MAS1 receptor (MAS), and facilitates viral entry and replication in kidney cells. COVID-19-associated endotheliopathy that interacts with other cell types, such as neutrophils, platelets, and macrophages, is one factor that accelerates prethrombotic reactions and thrombus formation, resulting in organ failures in diabetes. Apart from targeting vital signaling through ACE2 and MAS, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are also associated with higher profibrotic dipeptidyl transferase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK) activation in kidney cells. Lowered DPP-4 levels and restoration of AMPK levels are organ-protective, suggesting a pathogenic role of DPP-4 and a protective role of AMPK in diabetic COVID-19 patients. In addition to standard care provided to COVID-19 patients, we urgently need novel drug therapies that support the stability and function of both organs and cell types in diabetes.
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spelling pubmed-83988612021-08-29 Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease Srivastava, Swayam Prakash Srivastava, Rohit Chand, Subhash Goodwin, Julie E. Pharmaceuticals (Basel) Review The present review describes COVID-19 severity in diabetes and diabetic kidney disease. We discuss the crucial effect of COVID-19-associated cytokine storm and linked injuries and associated severe mesenchymal activation in tubular epithelial cells, endothelial cells, and macrophages that influence neighboring cell homeostasis, resulting in severe proteinuria and organ fibrosis in diabetes. Altered microRNA expression disrupts cellular homeostasis and the renin-angiotensin-system, targets reno-protective signaling proteins, such as angiotensin-converting enzyme 2 (ACE2) and MAS1 receptor (MAS), and facilitates viral entry and replication in kidney cells. COVID-19-associated endotheliopathy that interacts with other cell types, such as neutrophils, platelets, and macrophages, is one factor that accelerates prethrombotic reactions and thrombus formation, resulting in organ failures in diabetes. Apart from targeting vital signaling through ACE2 and MAS, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are also associated with higher profibrotic dipeptidyl transferase-4 (DPP-4)-mediated mechanisms and suppression of AMP-activated protein kinase (AMPK) activation in kidney cells. Lowered DPP-4 levels and restoration of AMPK levels are organ-protective, suggesting a pathogenic role of DPP-4 and a protective role of AMPK in diabetic COVID-19 patients. In addition to standard care provided to COVID-19 patients, we urgently need novel drug therapies that support the stability and function of both organs and cell types in diabetes. MDPI 2021-07-30 /pmc/articles/PMC8398861/ /pubmed/34451848 http://dx.doi.org/10.3390/ph14080751 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Srivastava, Swayam Prakash
Srivastava, Rohit
Chand, Subhash
Goodwin, Julie E.
Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title_full Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title_fullStr Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title_full_unstemmed Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title_short Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease
title_sort coronavirus disease (covid)-19 and diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398861/
https://www.ncbi.nlm.nih.gov/pubmed/34451848
http://dx.doi.org/10.3390/ph14080751
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