Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients

The treatment options for cytomegalovirus (CMV) infections in immunosuppressed patients are limited, mainly consisting of (val-)ganciclovir (VGC/GCV) as the first-line treatment. We report on three transplant recipients, one stem cell transplant (allo-HSCT) patient and two kidney transplant (KTx) re...

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Autores principales: Di Cristanziano, Veronica, Affeldt, Patrick, Trappe, Moritz, Wirtz, Maike, Heger, Eva, Knops, Elena, Kaiser, Rolf, Stippel, Dirk, Müller, Roman-Ulrich, Holtick, Udo, Scheid, Christoph, Kann, Martin, Kurschat, Christine E., Grundmann, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398864/
https://www.ncbi.nlm.nih.gov/pubmed/34442744
http://dx.doi.org/10.3390/microorganisms9081666
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author Di Cristanziano, Veronica
Affeldt, Patrick
Trappe, Moritz
Wirtz, Maike
Heger, Eva
Knops, Elena
Kaiser, Rolf
Stippel, Dirk
Müller, Roman-Ulrich
Holtick, Udo
Scheid, Christoph
Kann, Martin
Kurschat, Christine E.
Grundmann, Franziska
author_facet Di Cristanziano, Veronica
Affeldt, Patrick
Trappe, Moritz
Wirtz, Maike
Heger, Eva
Knops, Elena
Kaiser, Rolf
Stippel, Dirk
Müller, Roman-Ulrich
Holtick, Udo
Scheid, Christoph
Kann, Martin
Kurschat, Christine E.
Grundmann, Franziska
author_sort Di Cristanziano, Veronica
collection PubMed
description The treatment options for cytomegalovirus (CMV) infections in immunosuppressed patients are limited, mainly consisting of (val-)ganciclovir (VGC/GCV) as the first-line treatment. We report on three transplant recipients, one stem cell transplant (allo-HSCT) patient and two kidney transplant (KTx) recipients, with prolonged CMV viremia treated with a combined therapy based on letermovir (LMV), CMV-specific intravenous immunoglobulins (IVIg), and VGC/GCV, which led to the sustained control of CMV viremia in all patients.
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spelling pubmed-83988642021-08-29 Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients Di Cristanziano, Veronica Affeldt, Patrick Trappe, Moritz Wirtz, Maike Heger, Eva Knops, Elena Kaiser, Rolf Stippel, Dirk Müller, Roman-Ulrich Holtick, Udo Scheid, Christoph Kann, Martin Kurschat, Christine E. Grundmann, Franziska Microorganisms Case Report The treatment options for cytomegalovirus (CMV) infections in immunosuppressed patients are limited, mainly consisting of (val-)ganciclovir (VGC/GCV) as the first-line treatment. We report on three transplant recipients, one stem cell transplant (allo-HSCT) patient and two kidney transplant (KTx) recipients, with prolonged CMV viremia treated with a combined therapy based on letermovir (LMV), CMV-specific intravenous immunoglobulins (IVIg), and VGC/GCV, which led to the sustained control of CMV viremia in all patients. MDPI 2021-08-04 /pmc/articles/PMC8398864/ /pubmed/34442744 http://dx.doi.org/10.3390/microorganisms9081666 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Di Cristanziano, Veronica
Affeldt, Patrick
Trappe, Moritz
Wirtz, Maike
Heger, Eva
Knops, Elena
Kaiser, Rolf
Stippel, Dirk
Müller, Roman-Ulrich
Holtick, Udo
Scheid, Christoph
Kann, Martin
Kurschat, Christine E.
Grundmann, Franziska
Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title_full Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title_fullStr Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title_full_unstemmed Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title_short Combined Therapy with Intravenous Immunoglobulins, Letermovir and (Val-)Ganciclovir in Complicated Courses of CMV-Infection in Transplant Recipients
title_sort combined therapy with intravenous immunoglobulins, letermovir and (val-)ganciclovir in complicated courses of cmv-infection in transplant recipients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398864/
https://www.ncbi.nlm.nih.gov/pubmed/34442744
http://dx.doi.org/10.3390/microorganisms9081666
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