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The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital

Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic disease...

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Autores principales: Constantin, Maria-Magdalena, Bucur, Stefana, Mutu, Costina-Cristiana, Poenaru, Elena, Olteanu, Rodica, Ionescu, Razvan Adrian, Nicolescu, Alin Codrut, Furtunescu, Florentina, Constantin, Traian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398891/
https://www.ncbi.nlm.nih.gov/pubmed/34442396
http://dx.doi.org/10.3390/jpm11080752
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author Constantin, Maria-Magdalena
Bucur, Stefana
Mutu, Costina-Cristiana
Poenaru, Elena
Olteanu, Rodica
Ionescu, Razvan Adrian
Nicolescu, Alin Codrut
Furtunescu, Florentina
Constantin, Traian
author_facet Constantin, Maria-Magdalena
Bucur, Stefana
Mutu, Costina-Cristiana
Poenaru, Elena
Olteanu, Rodica
Ionescu, Razvan Adrian
Nicolescu, Alin Codrut
Furtunescu, Florentina
Constantin, Traian
author_sort Constantin, Maria-Magdalena
collection PubMed
description Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic diseases, such as oncologic or cardiovascular disease. Several risk factors, such as infections, stress, smoking, excessive alcohol consumption and genetic predisposition have been involved in inducing psoriasis. Smoking status is a risk factor for many chronic diseases, including psoriasis. Moreover, recent studies have tried to answer the question of whether smoking also influences the response to biologic therapy in patients with psoriasis. Through the current study, our intention is to find out how smoking affects the response to biologic treatment. A hospital-based cross-sectional, observational, non-interventional, retrospective study of moderate and severe psoriasis patients receiving biologic treatment was developed. Two groups were defined based on smoking status: group 1 included smokers (more than 10 cigarettes/day) and former smokers, and group 2 included non-smokers. The data that resulted from the analysis of the cohort of patients demonstrate that smoking status does not affect the response of biologic therapy in patients with moderate and severe psoriasis.
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spelling pubmed-83988912021-08-29 The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital Constantin, Maria-Magdalena Bucur, Stefana Mutu, Costina-Cristiana Poenaru, Elena Olteanu, Rodica Ionescu, Razvan Adrian Nicolescu, Alin Codrut Furtunescu, Florentina Constantin, Traian J Pers Med Article Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic diseases, such as oncologic or cardiovascular disease. Several risk factors, such as infections, stress, smoking, excessive alcohol consumption and genetic predisposition have been involved in inducing psoriasis. Smoking status is a risk factor for many chronic diseases, including psoriasis. Moreover, recent studies have tried to answer the question of whether smoking also influences the response to biologic therapy in patients with psoriasis. Through the current study, our intention is to find out how smoking affects the response to biologic treatment. A hospital-based cross-sectional, observational, non-interventional, retrospective study of moderate and severe psoriasis patients receiving biologic treatment was developed. Two groups were defined based on smoking status: group 1 included smokers (more than 10 cigarettes/day) and former smokers, and group 2 included non-smokers. The data that resulted from the analysis of the cohort of patients demonstrate that smoking status does not affect the response of biologic therapy in patients with moderate and severe psoriasis. MDPI 2021-07-30 /pmc/articles/PMC8398891/ /pubmed/34442396 http://dx.doi.org/10.3390/jpm11080752 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Constantin, Maria-Magdalena
Bucur, Stefana
Mutu, Costina-Cristiana
Poenaru, Elena
Olteanu, Rodica
Ionescu, Razvan Adrian
Nicolescu, Alin Codrut
Furtunescu, Florentina
Constantin, Traian
The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title_full The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title_fullStr The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title_full_unstemmed The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title_short The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
title_sort impact of smoking on psoriasis patients with biological therapies in a bucharest hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398891/
https://www.ncbi.nlm.nih.gov/pubmed/34442396
http://dx.doi.org/10.3390/jpm11080752
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