Cargando…
The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital
Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic disease...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398891/ https://www.ncbi.nlm.nih.gov/pubmed/34442396 http://dx.doi.org/10.3390/jpm11080752 |
_version_ | 1783744946418745344 |
---|---|
author | Constantin, Maria-Magdalena Bucur, Stefana Mutu, Costina-Cristiana Poenaru, Elena Olteanu, Rodica Ionescu, Razvan Adrian Nicolescu, Alin Codrut Furtunescu, Florentina Constantin, Traian |
author_facet | Constantin, Maria-Magdalena Bucur, Stefana Mutu, Costina-Cristiana Poenaru, Elena Olteanu, Rodica Ionescu, Razvan Adrian Nicolescu, Alin Codrut Furtunescu, Florentina Constantin, Traian |
author_sort | Constantin, Maria-Magdalena |
collection | PubMed |
description | Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic diseases, such as oncologic or cardiovascular disease. Several risk factors, such as infections, stress, smoking, excessive alcohol consumption and genetic predisposition have been involved in inducing psoriasis. Smoking status is a risk factor for many chronic diseases, including psoriasis. Moreover, recent studies have tried to answer the question of whether smoking also influences the response to biologic therapy in patients with psoriasis. Through the current study, our intention is to find out how smoking affects the response to biologic treatment. A hospital-based cross-sectional, observational, non-interventional, retrospective study of moderate and severe psoriasis patients receiving biologic treatment was developed. Two groups were defined based on smoking status: group 1 included smokers (more than 10 cigarettes/day) and former smokers, and group 2 included non-smokers. The data that resulted from the analysis of the cohort of patients demonstrate that smoking status does not affect the response of biologic therapy in patients with moderate and severe psoriasis. |
format | Online Article Text |
id | pubmed-8398891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83988912021-08-29 The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital Constantin, Maria-Magdalena Bucur, Stefana Mutu, Costina-Cristiana Poenaru, Elena Olteanu, Rodica Ionescu, Razvan Adrian Nicolescu, Alin Codrut Furtunescu, Florentina Constantin, Traian J Pers Med Article Psoriasis is an immune-mediated chronic inflammatory skin disease with extracutaneous manifestations, that affects about 1–3% of the world’s population. The disease is not life-threatening, but the disability which comes with it is comparable to the disability caused by other serious chronic diseases, such as oncologic or cardiovascular disease. Several risk factors, such as infections, stress, smoking, excessive alcohol consumption and genetic predisposition have been involved in inducing psoriasis. Smoking status is a risk factor for many chronic diseases, including psoriasis. Moreover, recent studies have tried to answer the question of whether smoking also influences the response to biologic therapy in patients with psoriasis. Through the current study, our intention is to find out how smoking affects the response to biologic treatment. A hospital-based cross-sectional, observational, non-interventional, retrospective study of moderate and severe psoriasis patients receiving biologic treatment was developed. Two groups were defined based on smoking status: group 1 included smokers (more than 10 cigarettes/day) and former smokers, and group 2 included non-smokers. The data that resulted from the analysis of the cohort of patients demonstrate that smoking status does not affect the response of biologic therapy in patients with moderate and severe psoriasis. MDPI 2021-07-30 /pmc/articles/PMC8398891/ /pubmed/34442396 http://dx.doi.org/10.3390/jpm11080752 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Constantin, Maria-Magdalena Bucur, Stefana Mutu, Costina-Cristiana Poenaru, Elena Olteanu, Rodica Ionescu, Razvan Adrian Nicolescu, Alin Codrut Furtunescu, Florentina Constantin, Traian The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title | The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title_full | The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title_fullStr | The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title_full_unstemmed | The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title_short | The Impact of Smoking on Psoriasis Patients with Biological Therapies in a Bucharest Hospital |
title_sort | impact of smoking on psoriasis patients with biological therapies in a bucharest hospital |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398891/ https://www.ncbi.nlm.nih.gov/pubmed/34442396 http://dx.doi.org/10.3390/jpm11080752 |
work_keys_str_mv | AT constantinmariamagdalena theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT bucurstefana theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT mutucostinacristiana theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT poenaruelena theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT olteanurodica theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT ionescurazvanadrian theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT nicolescualincodrut theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT furtunescuflorentina theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT constantintraian theimpactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT constantinmariamagdalena impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT bucurstefana impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT mutucostinacristiana impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT poenaruelena impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT olteanurodica impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT ionescurazvanadrian impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT nicolescualincodrut impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT furtunescuflorentina impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital AT constantintraian impactofsmokingonpsoriasispatientswithbiologicaltherapiesinabucharesthospital |