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Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo

Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-...

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Autores principales: Pishavar, Elham, Khosravi, Fatemeh, Naserifar, Mahshid, Rezvani Ghomi, Erfan, Luo, Hongrong, Zavan, Barbara, Seifalian, Amelia, Ramakrishna, Seeram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399012/
https://www.ncbi.nlm.nih.gov/pubmed/34451220
http://dx.doi.org/10.3390/polym13162680
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author Pishavar, Elham
Khosravi, Fatemeh
Naserifar, Mahshid
Rezvani Ghomi, Erfan
Luo, Hongrong
Zavan, Barbara
Seifalian, Amelia
Ramakrishna, Seeram
author_facet Pishavar, Elham
Khosravi, Fatemeh
Naserifar, Mahshid
Rezvani Ghomi, Erfan
Luo, Hongrong
Zavan, Barbara
Seifalian, Amelia
Ramakrishna, Seeram
author_sort Pishavar, Elham
collection PubMed
description Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-extracellular matrix (ECM) in cell biology, tissue engineering, and drug screening over the past two decades. In addition, hydrogels with a high capacity for drug loading and sustained release profile are applicable in drug delivery systems. Recently, self-healing supramolecular hydrogels, as a novel class of biomaterials, are being used in preclinical trials with benefits such as biocompatibility, native tissue mimicry, and injectability via a reversible crosslink. Meanwhile, the localized therapeutics agent delivery is beneficial due to the ability to deliver more doses of therapeutic agents to the targeted site and the ability to overcome post-surgical complications, inflammation, and infections. These highly potential materials can help address the limitations of current drug delivery systems and the high clinical demand for customized drug release systems. To this aim, the current review presents the state-of-the-art progress of multifunctional and self-healable hydrogels for a broad range of applications in cancer therapy, tissue engineering, and regenerative medicine.
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spelling pubmed-83990122021-08-29 Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo Pishavar, Elham Khosravi, Fatemeh Naserifar, Mahshid Rezvani Ghomi, Erfan Luo, Hongrong Zavan, Barbara Seifalian, Amelia Ramakrishna, Seeram Polymers (Basel) Review Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-extracellular matrix (ECM) in cell biology, tissue engineering, and drug screening over the past two decades. In addition, hydrogels with a high capacity for drug loading and sustained release profile are applicable in drug delivery systems. Recently, self-healing supramolecular hydrogels, as a novel class of biomaterials, are being used in preclinical trials with benefits such as biocompatibility, native tissue mimicry, and injectability via a reversible crosslink. Meanwhile, the localized therapeutics agent delivery is beneficial due to the ability to deliver more doses of therapeutic agents to the targeted site and the ability to overcome post-surgical complications, inflammation, and infections. These highly potential materials can help address the limitations of current drug delivery systems and the high clinical demand for customized drug release systems. To this aim, the current review presents the state-of-the-art progress of multifunctional and self-healable hydrogels for a broad range of applications in cancer therapy, tissue engineering, and regenerative medicine. MDPI 2021-08-11 /pmc/articles/PMC8399012/ /pubmed/34451220 http://dx.doi.org/10.3390/polym13162680 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pishavar, Elham
Khosravi, Fatemeh
Naserifar, Mahshid
Rezvani Ghomi, Erfan
Luo, Hongrong
Zavan, Barbara
Seifalian, Amelia
Ramakrishna, Seeram
Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title_full Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title_fullStr Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title_full_unstemmed Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title_short Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo
title_sort multifunctional and self-healable intelligent hydrogels for cancer drug delivery and promoting tissue regeneration in vivo
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399012/
https://www.ncbi.nlm.nih.gov/pubmed/34451220
http://dx.doi.org/10.3390/polym13162680
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