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Association between Olaparib Exposure and Early Toxicity in BRCA-Mutated Ovarian Cancer Patients: Results from a Retrospective Multicenter Study

Factors associated with olaparib toxicity remain unknown in ovarian cancer patients. The large inter-individual variability in olaparib pharmacokinetics could contribute to the onset of early significant adverse events (SAE). We aimed to retrospectively analyze the pharmacokinetic/pharmacodynamic re...

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Detalles Bibliográficos
Autores principales:	Velev, Maud, Puszkiel, Alicja, Blanchet, Benoit, de Percin, Sixtine, Delanoy, Nicolas, Medioni, Jacques, Gervais, Claire, Balakirouchenane, David, Khoudour, Nihel, Pautier, Patricia, Leary, Alexandra, Ajgal, Zahra, Hirsch, Laure, Goldwasser, François, Alexandre, Jerome, Beinse, Guillaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399031/ https://www.ncbi.nlm.nih.gov/pubmed/34451901 http://dx.doi.org/10.3390/ph14080804

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