Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in drug discovery research, a cell model that can precisely recapitulate the in vivo human intestinal monolayer is desired. In this study, we de...

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Detalles Bibliográficos
Autores principales: Yamashita, Tomoki, Inui, Tatsuya, Yokota, Jumpei, Kawakami, Kentaro, Morinaga, Gaku, Takatani, Masahito, Hirayama, Daisuke, Nomoto, Ryuga, Ito, Kohei, Cui, Yunhai, Ruez, Stephanie, Harada, Kazuo, Kishimoto, Wataru, Nakase, Hiroshi, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399089/
https://www.ncbi.nlm.nih.gov/pubmed/34485610
http://dx.doi.org/10.1016/j.omtm.2021.05.005

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