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Rush Hour of LATs towards Their Transport Cycle
The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399266/ https://www.ncbi.nlm.nih.gov/pubmed/34436365 http://dx.doi.org/10.3390/membranes11080602 |
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author | Nicolàs-Aragó, Adrià Fort, Joana Palacín, Manuel Errasti-Murugarren, Ekaitz |
author_facet | Nicolàs-Aragó, Adrià Fort, Joana Palacín, Manuel Errasti-Murugarren, Ekaitz |
author_sort | Nicolàs-Aragó, Adrià |
collection | PubMed |
description | The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In the last four years, several crystal or cryo-EM structures of LATs and CATs have been solved. These structures have started to fill our knowledge gap that previously was based on the structural biology of remote homologs of the amino acid–polyamine–organocation (APC) transporters. This review recovers this structural and functional information to start generating the molecular bases of the transport cycle of LATs. Special attention is given to the known transporter conformations within the transport cycle and the molecular bases for substrate interaction and translocation, including the asymmetric interaction of substrates at both sides of the plasma membrane. |
format | Online Article Text |
id | pubmed-8399266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83992662021-08-29 Rush Hour of LATs towards Their Transport Cycle Nicolàs-Aragó, Adrià Fort, Joana Palacín, Manuel Errasti-Murugarren, Ekaitz Membranes (Basel) Review The mammalian SLC7 family comprises the L-amino acid transporters (LATs) and the cationic amino acid transporters (CATs). The relevance of these transporters is highlighted by their involvement in several human pathologies, including inherited rare diseases and acquired diseases, such as cancer. In the last four years, several crystal or cryo-EM structures of LATs and CATs have been solved. These structures have started to fill our knowledge gap that previously was based on the structural biology of remote homologs of the amino acid–polyamine–organocation (APC) transporters. This review recovers this structural and functional information to start generating the molecular bases of the transport cycle of LATs. Special attention is given to the known transporter conformations within the transport cycle and the molecular bases for substrate interaction and translocation, including the asymmetric interaction of substrates at both sides of the plasma membrane. MDPI 2021-08-08 /pmc/articles/PMC8399266/ /pubmed/34436365 http://dx.doi.org/10.3390/membranes11080602 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nicolàs-Aragó, Adrià Fort, Joana Palacín, Manuel Errasti-Murugarren, Ekaitz Rush Hour of LATs towards Their Transport Cycle |
title | Rush Hour of LATs towards Their Transport Cycle |
title_full | Rush Hour of LATs towards Their Transport Cycle |
title_fullStr | Rush Hour of LATs towards Their Transport Cycle |
title_full_unstemmed | Rush Hour of LATs towards Their Transport Cycle |
title_short | Rush Hour of LATs towards Their Transport Cycle |
title_sort | rush hour of lats towards their transport cycle |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399266/ https://www.ncbi.nlm.nih.gov/pubmed/34436365 http://dx.doi.org/10.3390/membranes11080602 |
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