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Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399283/ https://www.ncbi.nlm.nih.gov/pubmed/34440510 http://dx.doi.org/10.3390/life11080766 |
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author | Sun, Jianguo Gao, Miaomiao Jiang, Daqing |
author_facet | Sun, Jianguo Gao, Miaomiao Jiang, Daqing |
author_sort | Sun, Jianguo |
collection | PubMed |
description | This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consists of an ergodic stationary distribution. Furthermore, we obtain the existence and uniqueness of the global positive solution by constructing a suitable Lyapunov function. Finally, we illustrate our results by numerical simulation. |
format | Online Article Text |
id | pubmed-8399283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83992832021-08-29 Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness Sun, Jianguo Gao, Miaomiao Jiang, Daqing Life (Basel) Article This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consists of an ergodic stationary distribution. Furthermore, we obtain the existence and uniqueness of the global positive solution by constructing a suitable Lyapunov function. Finally, we illustrate our results by numerical simulation. MDPI 2021-07-29 /pmc/articles/PMC8399283/ /pubmed/34440510 http://dx.doi.org/10.3390/life11080766 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Jianguo Gao, Miaomiao Jiang, Daqing Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title | Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title_full | Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title_fullStr | Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title_full_unstemmed | Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title_short | Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness |
title_sort | threshold dynamics of a non-linear stochastic viral model with time delay and ctl responsiveness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399283/ https://www.ncbi.nlm.nih.gov/pubmed/34440510 http://dx.doi.org/10.3390/life11080766 |
work_keys_str_mv | AT sunjianguo thresholddynamicsofanonlinearstochasticviralmodelwithtimedelayandctlresponsiveness AT gaomiaomiao thresholddynamicsofanonlinearstochasticviralmodelwithtimedelayandctlresponsiveness AT jiangdaqing thresholddynamicsofanonlinearstochasticviralmodelwithtimedelayandctlresponsiveness |