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Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness

This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consi...

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Detalles Bibliográficos
Autores principales: Sun, Jianguo, Gao, Miaomiao, Jiang, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399283/
https://www.ncbi.nlm.nih.gov/pubmed/34440510
http://dx.doi.org/10.3390/life11080766
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author Sun, Jianguo
Gao, Miaomiao
Jiang, Daqing
author_facet Sun, Jianguo
Gao, Miaomiao
Jiang, Daqing
author_sort Sun, Jianguo
collection PubMed
description This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consists of an ergodic stationary distribution. Furthermore, we obtain the existence and uniqueness of the global positive solution by constructing a suitable Lyapunov function. Finally, we illustrate our results by numerical simulation.
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spelling pubmed-83992832021-08-29 Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness Sun, Jianguo Gao, Miaomiao Jiang, Daqing Life (Basel) Article This article focuses on a stochastic viral model with distributed delay and CTL responsiveness. It is shown that the viral disease will be extinct if the stochastic reproductive ratio is less than one. However, when the stochastic reproductive ratio is more than one, the viral infection system consists of an ergodic stationary distribution. Furthermore, we obtain the existence and uniqueness of the global positive solution by constructing a suitable Lyapunov function. Finally, we illustrate our results by numerical simulation. MDPI 2021-07-29 /pmc/articles/PMC8399283/ /pubmed/34440510 http://dx.doi.org/10.3390/life11080766 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Jianguo
Gao, Miaomiao
Jiang, Daqing
Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title_full Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title_fullStr Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title_full_unstemmed Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title_short Threshold Dynamics of a Non-Linear Stochastic Viral Model with Time Delay and CTL Responsiveness
title_sort threshold dynamics of a non-linear stochastic viral model with time delay and ctl responsiveness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399283/
https://www.ncbi.nlm.nih.gov/pubmed/34440510
http://dx.doi.org/10.3390/life11080766
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