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Assessment of Phenotype Relevant Amino Acid Residues in TEM-β-Lactamases by Mathematical Modelling and Experimental Approval

Single substitutions or combinations of them alter the hydrolytic activity towards specific β-lactam-antibiotics and β-lactamase inhibitors of TEM-β-lactamases. The sequences and phenotypic classification of allelic TEM variants, as provided by the NCBI National Database of Antibiotic Resistant Orga...

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Detalles Bibliográficos
Autores principales:	Madzgalla, Sara, Duering, Helena, Hey, Jana C., Neubauer, Svetlana, Feller, Karl-Heinz, Ehricht, Ralf, Pletz, Mathias W., Makarewicz, Oliwia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399295/ https://www.ncbi.nlm.nih.gov/pubmed/34442804 http://dx.doi.org/10.3390/microorganisms9081726

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