Cargando…

General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results

Febrile seizures (FS) affect up to 5% of children. The pathogen etiology in regard of viral loads has never been investigated. In a prospective cohort study we investigated the correlation between virus type and quantity in nasopharyngeal aspirates (NPAs) and the clinical characteristics in pediatri...

Descripción completa

Detalles Bibliográficos
Autores principales: Rudolph, Henriette, Gress, Katharina, Weiss, Christel, Schroten, Horst, Adams, Ortwin, Tenenbaum, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399297/
https://www.ncbi.nlm.nih.gov/pubmed/34451525
http://dx.doi.org/10.3390/pathogens10081061
_version_ 1783745043221184512
author Rudolph, Henriette
Gress, Katharina
Weiss, Christel
Schroten, Horst
Adams, Ortwin
Tenenbaum, Tobias
author_facet Rudolph, Henriette
Gress, Katharina
Weiss, Christel
Schroten, Horst
Adams, Ortwin
Tenenbaum, Tobias
author_sort Rudolph, Henriette
collection PubMed
description Febrile seizures (FS) affect up to 5% of children. The pathogen etiology in regard of viral loads has never been investigated. In a prospective cohort study we investigated the correlation between virus type and quantity in nasopharyngeal aspirates (NPAs) and the clinical characteristics in pediatric patients with a FS. From January 2014 to April 2016, 184 children with a FS were prospectively enrolled. The mean age of all included children was 26.7 ± 18.3 months with a male to female ratio of 1.4:1. Males with an acute disease and a short duration or absence of prior symptoms had a higher risk for complex FS. The majority of patients with FS presented with a generalized convulsion (180; 98%) and was admitted to hospital (178; 97%). Overall, 79 (43%) single and in 59 (32%) co-infections were detected. Human herpes virus 6 (HHV6), influenza, adenovirus (AV) and rhinovirus (RV) were the dominant pathogens, all detected with clinically significant high viral loads. HHV6 positive cases were significantly younger and less likely to have a positive family/personal history for FS. Influenza positives showed a higher rate of complex seizures, lower leukocyte and higher monocyte counts. AV positive cases were more likely to have a positive family history for FS and showed higher C-reactive protein values. In conclusion, a high viral load may contribute to the development of a FS in respiratory tract infections.
format Online
Article
Text
id pubmed-8399297
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83992972021-08-29 General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results Rudolph, Henriette Gress, Katharina Weiss, Christel Schroten, Horst Adams, Ortwin Tenenbaum, Tobias Pathogens Article Febrile seizures (FS) affect up to 5% of children. The pathogen etiology in regard of viral loads has never been investigated. In a prospective cohort study we investigated the correlation between virus type and quantity in nasopharyngeal aspirates (NPAs) and the clinical characteristics in pediatric patients with a FS. From January 2014 to April 2016, 184 children with a FS were prospectively enrolled. The mean age of all included children was 26.7 ± 18.3 months with a male to female ratio of 1.4:1. Males with an acute disease and a short duration or absence of prior symptoms had a higher risk for complex FS. The majority of patients with FS presented with a generalized convulsion (180; 98%) and was admitted to hospital (178; 97%). Overall, 79 (43%) single and in 59 (32%) co-infections were detected. Human herpes virus 6 (HHV6), influenza, adenovirus (AV) and rhinovirus (RV) were the dominant pathogens, all detected with clinically significant high viral loads. HHV6 positive cases were significantly younger and less likely to have a positive family/personal history for FS. Influenza positives showed a higher rate of complex seizures, lower leukocyte and higher monocyte counts. AV positive cases were more likely to have a positive family history for FS and showed higher C-reactive protein values. In conclusion, a high viral load may contribute to the development of a FS in respiratory tract infections. MDPI 2021-08-20 /pmc/articles/PMC8399297/ /pubmed/34451525 http://dx.doi.org/10.3390/pathogens10081061 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rudolph, Henriette
Gress, Katharina
Weiss, Christel
Schroten, Horst
Adams, Ortwin
Tenenbaum, Tobias
General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title_full General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title_fullStr General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title_full_unstemmed General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title_short General Characteristics of Children with Single- and Co-Infections and Febrile Seizures with a Main Focus on Respiratory Pathogens: Preliminary Results
title_sort general characteristics of children with single- and co-infections and febrile seizures with a main focus on respiratory pathogens: preliminary results
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399297/
https://www.ncbi.nlm.nih.gov/pubmed/34451525
http://dx.doi.org/10.3390/pathogens10081061
work_keys_str_mv AT rudolphhenriette generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults
AT gresskatharina generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults
AT weisschristel generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults
AT schrotenhorst generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults
AT adamsortwin generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults
AT tenenbaumtobias generalcharacteristicsofchildrenwithsingleandcoinfectionsandfebrileseizureswithamainfocusonrespiratorypathogenspreliminaryresults