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Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19
Background and Objectives: To evaluate the performance of antigen-based detection tests as the frontline diagnosis of coronavirus disease 2019 (COVID-19). Materials and Methods: We conducted a nationwide retrospective cohort study in Mexico. A cross-sectional analysis of a cohort study was conducted...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399338/ https://www.ncbi.nlm.nih.gov/pubmed/34441058 http://dx.doi.org/10.3390/medicina57080852 |
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author | Murillo-Zamora, Efrén Trujillo, Xóchitl Huerta, Miguel Ríos-Silva, Mónica Mendoza-Cano, Oliver |
author_facet | Murillo-Zamora, Efrén Trujillo, Xóchitl Huerta, Miguel Ríos-Silva, Mónica Mendoza-Cano, Oliver |
author_sort | Murillo-Zamora, Efrén |
collection | PubMed |
description | Background and Objectives: To evaluate the performance of antigen-based detection tests as the frontline diagnosis of coronavirus disease 2019 (COVID-19). Materials and Methods: We conducted a nationwide retrospective cohort study in Mexico. A cross-sectional analysis of a cohort study was conducted in Mexico and data from 15,408 suspected (all of them symptomatic) cases of COVID-19 were analyzed. The results of antigen-based tests were compared with those obtained by molecular (polymerase chain reaction-based) assays. Results: The antigen-based tests showed sensitivity below 50% and high specificity in all the analyzed age groups. The highest Youden index (J) was observed among adults aged 25–44 years old (45.5, 95% CI 43.7–47.3). Conclusions: We documented the poor performance of serologic techniques as frontline diagnosis of symptomatic COVID-19 and inaccurate results may impact negatively on pandemic progression. |
format | Online Article Text |
id | pubmed-8399338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83993382021-08-29 Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 Murillo-Zamora, Efrén Trujillo, Xóchitl Huerta, Miguel Ríos-Silva, Mónica Mendoza-Cano, Oliver Medicina (Kaunas) Article Background and Objectives: To evaluate the performance of antigen-based detection tests as the frontline diagnosis of coronavirus disease 2019 (COVID-19). Materials and Methods: We conducted a nationwide retrospective cohort study in Mexico. A cross-sectional analysis of a cohort study was conducted in Mexico and data from 15,408 suspected (all of them symptomatic) cases of COVID-19 were analyzed. The results of antigen-based tests were compared with those obtained by molecular (polymerase chain reaction-based) assays. Results: The antigen-based tests showed sensitivity below 50% and high specificity in all the analyzed age groups. The highest Youden index (J) was observed among adults aged 25–44 years old (45.5, 95% CI 43.7–47.3). Conclusions: We documented the poor performance of serologic techniques as frontline diagnosis of symptomatic COVID-19 and inaccurate results may impact negatively on pandemic progression. MDPI 2021-08-21 /pmc/articles/PMC8399338/ /pubmed/34441058 http://dx.doi.org/10.3390/medicina57080852 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Murillo-Zamora, Efrén Trujillo, Xóchitl Huerta, Miguel Ríos-Silva, Mónica Mendoza-Cano, Oliver Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title | Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title_full | Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title_fullStr | Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title_full_unstemmed | Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title_short | Performance of Antigen-Based Testing as Frontline Diagnosis of Symptomatic COVID-19 |
title_sort | performance of antigen-based testing as frontline diagnosis of symptomatic covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399338/ https://www.ncbi.nlm.nih.gov/pubmed/34441058 http://dx.doi.org/10.3390/medicina57080852 |
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