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Monitoring cell-mediated immune responses in AAV gene therapy clinical trials using a validated IFN-γ ELISpot method

Adeno-associated virus (AAV)-based gene therapies have recently shown promise as a novel treatment for hereditary diseases. Due to the viral origin of the vector capsid, however, cellular immune response may be elicited that could eliminate transduced target cells. To monitor cellular immune respons...

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Detalles Bibliográficos
Autores principales:	Patton, Kathryn S., Harrison, M. Travis, Long, Brian R., Lau, Kelly, Holcomb, Jennifer, Owen, Rachel, Kasprzyk, Theresa, Janetzki, Sylvia, Zoog, Stephen J., Vettermann, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399379/ https://www.ncbi.nlm.nih.gov/pubmed/34485604 http://dx.doi.org/10.1016/j.omtm.2021.05.012

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