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Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications
Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely it may help to prevent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399388/ https://www.ncbi.nlm.nih.gov/pubmed/34444706 http://dx.doi.org/10.3390/nu13082546 |
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author | Colletti, Alessandro Sangiorgio, Luciano Martelli, Alma Testai, Lara Cicero, Arrigo F. G. Cravotto, Giancarlo |
author_facet | Colletti, Alessandro Sangiorgio, Luciano Martelli, Alma Testai, Lara Cicero, Arrigo F. G. Cravotto, Giancarlo |
author_sort | Colletti, Alessandro |
collection | PubMed |
description | Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely it may help to prevent cardiovascular and gastroenteric diseases, as highlighted by several clinical trials. However, aiming to validate the efficacy and safety of clinical applications as long-term randomized clinical trials (RCTs), further investigations of the mechanisms of action are required. In addition, a real challenge for next years is the standardization of cranberry’s polyphenolic fractions. In this context, the optimization of the extraction process and downstream processing represent a key point for a reliable active principle for the formulation of a food supplement. For this reason, new non-conventional extraction methods have been developed to improve the quality of the extracts and reduce the overall costs. The aim of this survey is to describe both technologies and processes for highly active cranberry extracts as well as the effects observed in clinical studies and the respective tolerability notes. |
format | Online Article Text |
id | pubmed-8399388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83993882021-08-29 Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications Colletti, Alessandro Sangiorgio, Luciano Martelli, Alma Testai, Lara Cicero, Arrigo F. G. Cravotto, Giancarlo Nutrients Review Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely it may help to prevent cardiovascular and gastroenteric diseases, as highlighted by several clinical trials. However, aiming to validate the efficacy and safety of clinical applications as long-term randomized clinical trials (RCTs), further investigations of the mechanisms of action are required. In addition, a real challenge for next years is the standardization of cranberry’s polyphenolic fractions. In this context, the optimization of the extraction process and downstream processing represent a key point for a reliable active principle for the formulation of a food supplement. For this reason, new non-conventional extraction methods have been developed to improve the quality of the extracts and reduce the overall costs. The aim of this survey is to describe both technologies and processes for highly active cranberry extracts as well as the effects observed in clinical studies and the respective tolerability notes. MDPI 2021-07-26 /pmc/articles/PMC8399388/ /pubmed/34444706 http://dx.doi.org/10.3390/nu13082546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Colletti, Alessandro Sangiorgio, Luciano Martelli, Alma Testai, Lara Cicero, Arrigo F. G. Cravotto, Giancarlo Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title | Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title_full | Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title_fullStr | Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title_full_unstemmed | Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title_short | Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications |
title_sort | highly active cranberry’s polyphenolic fraction: new advances in processing and clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399388/ https://www.ncbi.nlm.nih.gov/pubmed/34444706 http://dx.doi.org/10.3390/nu13082546 |
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