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Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma

Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. The aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblast...

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Autores principales: Moosburner, Simon, Schmelzle, Moritz, Schöning, Wenzel, Kästner, Anika, Seika, Philippa, Globke, Brigitta, Dziodzio, Tomasz, Pratschke, Johann, Öllinger, Robert, Gül-Klein, Safak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399470/
https://www.ncbi.nlm.nih.gov/pubmed/34441025
http://dx.doi.org/10.3390/medicina57080819
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author Moosburner, Simon
Schmelzle, Moritz
Schöning, Wenzel
Kästner, Anika
Seika, Philippa
Globke, Brigitta
Dziodzio, Tomasz
Pratschke, Johann
Öllinger, Robert
Gül-Klein, Safak
author_facet Moosburner, Simon
Schmelzle, Moritz
Schöning, Wenzel
Kästner, Anika
Seika, Philippa
Globke, Brigitta
Dziodzio, Tomasz
Pratschke, Johann
Öllinger, Robert
Gül-Klein, Safak
author_sort Moosburner, Simon
collection PubMed
description Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. The aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and Methods: Retrospective analysis of all patients treated surgically for hepatoblastoma from January 2000 until December 2019 was performed. Demographic and clinical data were collected before and after surgery. The primary endpoints were disease free survival and patient survival. Results: In total, 38 patients were included into our analysis (n = 28 for LR, n = 10 for LT) with a median follow-up of 5 years. 36 patients received chemotherapy prior to surgery. Total hospital stay and intensive care unit (ICU) stay were significantly longer within the LT vs. the LR group (ICU 23 vs. 4 days, hospital stay 34 vs. 16 days, respectively; p < 0.001). Surgical complications (≤Clavien–Dindo 3a) were equally distributed in both groups (60% vs. 57%; p = 1.00). Severe complications (≥Clavien–Dindo 3a) were more frequent after LT (50% vs. 21.4%; p = 0.11). Recurrence rates were 10.7% for LR and 0% for LT at 5 years after resection or transplantation (p = 0.94). Overall, 5-year survival was 90% for LT and 96% for LR (p = 0.44). Conclusions: In irresectable cases, liver transplantation reveals excellent outcomes in children with hepatoblastoma with an acceptable number of perioperative complications.
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spelling pubmed-83994702021-08-29 Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma Moosburner, Simon Schmelzle, Moritz Schöning, Wenzel Kästner, Anika Seika, Philippa Globke, Brigitta Dziodzio, Tomasz Pratschke, Johann Öllinger, Robert Gül-Klein, Safak Medicina (Kaunas) Article Background and Objectives: In children, hepatoblastoma preferentially is managed by liver resection (LR). However, in irresectable cases, liver transplantation (LT) is required. The aim of our study was to compare short- and long-term results after LR and LT for the curative treatment of hepatoblastoma. Materials and Methods: Retrospective analysis of all patients treated surgically for hepatoblastoma from January 2000 until December 2019 was performed. Demographic and clinical data were collected before and after surgery. The primary endpoints were disease free survival and patient survival. Results: In total, 38 patients were included into our analysis (n = 28 for LR, n = 10 for LT) with a median follow-up of 5 years. 36 patients received chemotherapy prior to surgery. Total hospital stay and intensive care unit (ICU) stay were significantly longer within the LT vs. the LR group (ICU 23 vs. 4 days, hospital stay 34 vs. 16 days, respectively; p < 0.001). Surgical complications (≤Clavien–Dindo 3a) were equally distributed in both groups (60% vs. 57%; p = 1.00). Severe complications (≥Clavien–Dindo 3a) were more frequent after LT (50% vs. 21.4%; p = 0.11). Recurrence rates were 10.7% for LR and 0% for LT at 5 years after resection or transplantation (p = 0.94). Overall, 5-year survival was 90% for LT and 96% for LR (p = 0.44). Conclusions: In irresectable cases, liver transplantation reveals excellent outcomes in children with hepatoblastoma with an acceptable number of perioperative complications. MDPI 2021-08-12 /pmc/articles/PMC8399470/ /pubmed/34441025 http://dx.doi.org/10.3390/medicina57080819 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moosburner, Simon
Schmelzle, Moritz
Schöning, Wenzel
Kästner, Anika
Seika, Philippa
Globke, Brigitta
Dziodzio, Tomasz
Pratschke, Johann
Öllinger, Robert
Gül-Klein, Safak
Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title_full Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title_fullStr Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title_full_unstemmed Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title_short Liver Transplantation Is Highly Effective in Children with Irresectable Hepatoblastoma
title_sort liver transplantation is highly effective in children with irresectable hepatoblastoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399470/
https://www.ncbi.nlm.nih.gov/pubmed/34441025
http://dx.doi.org/10.3390/medicina57080819
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