Matrix Metalloproteinase-3 (MMP-3) Polymorphisms Are Associated with Prolonged ECG-Derived QTc Interval: A Cross-Sectional Study of the Australian Rural Population

Matrix metalloproteinases (MMPs) are enzymes that are integral in extracellular matrix (ECM) remodeling. In age or disease, ECM may become dysregulated and contribute to fibrosis, which impairs cardiac electrical conduction. Two alleles regulate matrix metalloproteinase-3 (MMP-3) activity: one with...

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Detalles Bibliográficos
Autores principales: Lu, Yaxin, Ussher, Nathan, Zhou, Yuling, Jelinek, Herbert, Hambly, Brett, Li, Amy, McLachlan, Craig S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399546/
https://www.ncbi.nlm.nih.gov/pubmed/34442348
http://dx.doi.org/10.3390/jpm11080705

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