Cargando…

In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands

The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this wor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stefanucci, Azzurra, Iobbi, Valeria, Della Valle, Alice, Scioli, Giuseppe, Pieretti, Stefano, Minosi, Paola, Mirzaie, Sako, Novellino, Ettore, Mollica, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399634/ https://www.ncbi.nlm.nih.gov/pubmed/34443366 http://dx.doi.org/10.3390/molecules26164767

Ejemplares similares

A Comparative Study on Phytochemical Fingerprint of Two Diverse Phaseolus vulgaris var. Tondino del Tavo and Cannellino Bio Extracts
por: Stefanucci, Azzurra, et al.
Publicado: (2022)

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity
por: Dimmito, Marilisa P., et al.
Publicado: (2019)

On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity
por: Stefanucci, Azzurra, et al.
Publicado: (2019)

Peptide Human Neutrophil Elastase Inhibitors from Natural Sources: An Overview
por: Marinaccio, Lorenza, et al.
Publicado: (2022)

Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides
por: Stefanucci, Azzurra, et al.
Publicado: (2018)

Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo
por: Mollica, Adriano, et al.
Publicado: (2021)

Exploring the Nutraceutical Potential of Dried Pepper Capsicum annuum L. on Market from Altino in Abruzzo Region
por: Della Valle, Alice, et al.
Publicado: (2020)

Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands
por: Dvorácskó, Szabolcs, et al.
Publicado: (2023)

Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties
por: Pieretti, Stefano, et al.
Publicado: (2022)

New Insights on Formyl Peptide Receptor Type 2 Involvement in Nociceptive Processes in the Spinal Cord
por: Colucci, Mariantonella, et al.
Publicado: (2022)

Mediterranean Edible Plants: An Assessment of Their Antioxidant, Radical Scavenger Properties and Their Use as Super Foods, Nutraceuticals, Functional Foods
por: Stefanucci, Azzurra, et al.
Publicado: (2021)

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors
por: Mollica, Adriano, et al.
Publicado: (2017)

Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems
por: Mollica, Adriano, et al.
Publicado: (2012)

Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists
por: Szűcs, Edina, et al.
Publicado: (2020)

Anti-Oxidant and Tyrosinase Inhibitory In Vitro Activity of Amino Acids and Small Peptides: New Hints for the Multifaceted Treatment of Neurologic and Metabolic Disfunctions
por: Luisi, Grazia, et al.
Publicado: (2018)

Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile(9)]PK20—The Effect of Isomerism of a Single Amino Acid
por: Żyżyńska-Granica, Barbara, et al.
Publicado: (2022)

Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control
por: Stefanucci, Azzurra, et al.
Publicado: (2011)

Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
por: Vernieri, Ermelinda, et al.
Publicado: (2013)

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators
por: Mollica, Adriano, et al.
Publicado: (2017)

Phenolic Profile, Toxicity, Enzyme Inhibition, In Silico Studies, and Antioxidant Properties of Cakile maritima Scop. (Brassicaceae) from Southern Portugal
por: Placines, Chloé, et al.
Publicado: (2020)

Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening
por: Poli, Giulio, et al.
Publicado: (2019)

Indole Inhibits IncP-1 Conjugation System Mainly Through Promoting korA and korB Expression
por: Xiong, Rui, et al.
Publicado: (2021)

A Study on Chemical Characterization and Biological Abilities of Alstonia boonei Extracts Obtained by Different Techniques
por: Mollica, Adriano, et al.
Publicado: (2022)

A single aromatic residue in transcriptional repressor protein KorA is critical for cooperativity with its co-regulator KorB
por: Bingle, Lewis E H, et al.
Publicado: (2008)

Intrinsic disorder in the partitioning protein KorB persists after co-operative complex formation with operator DNA and KorA
por: Hyde, Eva I., et al.
Publicado: (2017)

Evaluation of Antimicrobial Activities against Various E. coli Strains of a Novel Hybrid Peptide—LENART01
por: Serafin, Pawel, et al.
Publicado: (2023)

Ammonium Glycyrrhizinate Prevents Apoptosis and Mitochondrial Dysfunction Induced by High Glucose in SH-SY5Y Cell Line and Counteracts Neuropathic Pain in Streptozotocin-Induced Diabetic Mice
por: Ciarlo, Laura, et al.
Publicado: (2021)

Nanoformulations of natural products for management of metabolic syndrome
por: Taghipour, Yasamin Davatgaran, et al.
Publicado: (2019)

Guideline‐Directed Medical Therapy for Patients With Heart Failure With Midrange Ejection Fraction: A Patient‐Pooled Analysis From the KorHF and KorAHF Registries
por: Choi, Ki Hong, et al.
Publicado: (2018)

QSAR Study on Antioxidant Tripeptides and the Antioxidant Activity of the Designed Tripeptides in Free Radical Systems
por: Chen, Nan, et al.
Publicado: (2018)

LC-MS Based Analysis and Biological Properties of Pseudocedrela kotschyi (Schweinf.) Harms Extracts: A Valuable Source of Antioxidant, Antifungal, and Antibacterial Compounds
por: Sinan, Kouadio Ibrahime, et al.
Publicado: (2021)

Tripeptide analysis of protein structures
por: Anishetty, Sharmila, et al.
Publicado: (2002)

Isolation and Identification of Endosulfan-Degrading Bacteria and Evaluation of Their Bioremediation in Kor River, Iran
por: Kafilzadeh, Farshid, et al.
Publicado: (2014)

Understanding the Chemical Composition and Biological Activities of Different Extracts of Secamone afzelii Leaves: A Potential Source of Bioactive Compounds for the Food Industry
por: Sinan, Kouadio I., et al.
Publicado: (2023)

Controversy of Peptide Cyclization from Tripeptide
por: Lin, Chung-Yin, et al.
Publicado: (2021)

Identification of Di/Tripeptide(s) With Osteoblasts Proliferation Stimulation Abilities of Yak Bone Collagen by in silico Screening and Molecular Docking
por: Chen, Yongkai, et al.
Publicado: (2022)

Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
por: Rogachevskii, Ilya V., et al.
Publicado: (2022)

Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control
por: Orlando, Giustino, et al.
Publicado: (2018)

Establishment of the South Korean national antimicrobial resistance surveillance system, Kor-GLASS, in 2016
por: Lee, Hyukmin, et al.
Publicado: (2018)

Management and Prognosis of Heart Failure in Octogenarians: Final Report from the KorAHF Registry
por: Oh, Gyu Chul, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f9g2cnjkr26i90ib3m07f76mue