Cargando…

The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke

Background: Studies assessing the prognostic effect of inflammatory markers of blood cells on the outcomes of patients with acute ischemic stroke treated with endovascular treatment (EVT) are sparse. We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sang-Hwa, Jang, Min Uk, Kim, Yerim, Park, So Young, Kim, Chulho, Kim, Yeo Jin, Sohn, Jong-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399654/
https://www.ncbi.nlm.nih.gov/pubmed/34442341
http://dx.doi.org/10.3390/jpm11080696
_version_ 1783745129847193600
author Lee, Sang-Hwa
Jang, Min Uk
Kim, Yerim
Park, So Young
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
author_facet Lee, Sang-Hwa
Jang, Min Uk
Kim, Yerim
Park, So Young
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
author_sort Lee, Sang-Hwa
collection PubMed
description Background: Studies assessing the prognostic effect of inflammatory markers of blood cells on the outcomes of patients with acute ischemic stroke treated with endovascular treatment (EVT) are sparse. We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) affect reperfusion status in patients receiving EVT. Methods: Using a multicenter registry database, 282 patients treated with EVT were enrolled in this study. The primary outcome measure was unsuccessful reperfusion rate after EVT defined by thrombolysis in cerebral infarction grades 0–2a. Logistic regression analysis was performed to analyze the association between NLR/PLR and unsuccessful reperfusion rate after EVT. Results: Both NLR and PLR were higher in the unsuccessful reperfusion group than in the successful reperfusion group (p < 0.001). Multivariate analysis showed that both NLR and PLR were significantly associated with unsuccessful reperfusion (adjusted odds ratio (95% confidence interval): 1.11 (1.04–1.19), PLR: 1.004 (1.001–1.01)). The receiver operating characteristic curve showed that the predictive ability of both NLR and PLR was close to good (area under the curve (AUC) of NLR: 0.63, 95% CI (0.54–0.72), p < 0.001; AUC of PLR: 0.65, 95% CI (0.57–0.73), p < 0.001). The cutoff values of NLR and PLR were 6.2 and 103.6 for unsuccessful reperfusion, respectively. Conclusion: Higher NLR and PLR were associated with unsuccessful reperfusion after EVT. The combined application of both biomarkers could be useful for predicting outcomes after EVT.
format Online
Article
Text
id pubmed-8399654
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83996542021-08-29 The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke Lee, Sang-Hwa Jang, Min Uk Kim, Yerim Park, So Young Kim, Chulho Kim, Yeo Jin Sohn, Jong-Hee J Pers Med Article Background: Studies assessing the prognostic effect of inflammatory markers of blood cells on the outcomes of patients with acute ischemic stroke treated with endovascular treatment (EVT) are sparse. We evaluated whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) affect reperfusion status in patients receiving EVT. Methods: Using a multicenter registry database, 282 patients treated with EVT were enrolled in this study. The primary outcome measure was unsuccessful reperfusion rate after EVT defined by thrombolysis in cerebral infarction grades 0–2a. Logistic regression analysis was performed to analyze the association between NLR/PLR and unsuccessful reperfusion rate after EVT. Results: Both NLR and PLR were higher in the unsuccessful reperfusion group than in the successful reperfusion group (p < 0.001). Multivariate analysis showed that both NLR and PLR were significantly associated with unsuccessful reperfusion (adjusted odds ratio (95% confidence interval): 1.11 (1.04–1.19), PLR: 1.004 (1.001–1.01)). The receiver operating characteristic curve showed that the predictive ability of both NLR and PLR was close to good (area under the curve (AUC) of NLR: 0.63, 95% CI (0.54–0.72), p < 0.001; AUC of PLR: 0.65, 95% CI (0.57–0.73), p < 0.001). The cutoff values of NLR and PLR were 6.2 and 103.6 for unsuccessful reperfusion, respectively. Conclusion: Higher NLR and PLR were associated with unsuccessful reperfusion after EVT. The combined application of both biomarkers could be useful for predicting outcomes after EVT. MDPI 2021-07-22 /pmc/articles/PMC8399654/ /pubmed/34442341 http://dx.doi.org/10.3390/jpm11080696 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Sang-Hwa
Jang, Min Uk
Kim, Yerim
Park, So Young
Kim, Chulho
Kim, Yeo Jin
Sohn, Jong-Hee
The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title_full The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title_fullStr The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title_full_unstemmed The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title_short The Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Predict Reperfusion and Prognosis after Endovascular Treatment of Acute Ischemic Stroke
title_sort neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict reperfusion and prognosis after endovascular treatment of acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399654/
https://www.ncbi.nlm.nih.gov/pubmed/34442341
http://dx.doi.org/10.3390/jpm11080696
work_keys_str_mv AT leesanghwa theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT jangminuk theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimyerim theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT parksoyoung theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimchulho theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimyeojin theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT sohnjonghee theneutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT leesanghwa neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT jangminuk neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimyerim neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT parksoyoung neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimchulho neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT kimyeojin neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke
AT sohnjonghee neutrophiltolymphocyteandplatelettolymphocyteratiospredictreperfusionandprognosisafterendovasculartreatmentofacuteischemicstroke