Cargando…

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

BACKGROUND: The evolution of drug resistance is one of the biggest challenges in leishmaniasis and has prompted the need for new antileishmanial drugs. Repurposing of approved drugs is a faster and very attractive strategy that is gaining supporters worldwide. Different anticancer topoisomerase 1B (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosa-Teijeiro, Chloé, Wagner, Victoria, Corbeil, Audrey, d’Annessa, Ilda, Leprohon, Philippe, do Monte-Neto, Rubens L., Fernandez-Prada, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399852/ https://www.ncbi.nlm.nih.gov/pubmed/34454601 http://dx.doi.org/10.1186/s13071-021-04947-4

Ejemplares similares

Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA Complex
por: Mancini, Giordano, et al.
Publicado: (2010)

ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism
por: Sengupta, Souvik, et al.
Publicado: (2011)

MRPA-independent mechanisms of antimony resistance in Leishmania infantum
por: Douanne, Noélie, et al.
Publicado: (2020)

Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons
por: Roy, Amit, et al.
Publicado: (2011)

Drug resistance analysis by next generation sequencing in Leishmania
por: Leprohon, Philippe, et al.
Publicado: (2014)

A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance
por: Losasso, Carmen, et al.
Publicado: (2008)

Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum
por: Ritt, Jean-François, et al.
Publicado: (2013)

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB
por: Pérez-Pertejo, Yolanda, et al.
Publicado: (2019)

Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction
por: Mancini, Giordano, et al.
Publicado: (2012)

Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations
por: Chillemi, Giovanni, et al.
Publicado: (2008)

Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant
por: Arnò, Barbara, et al.
Publicado: (2013)

Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum
por: Roy, Amit, et al.
Publicado: (2011)

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum
por: Leprohon, Philippe, et al.
Publicado: (2009)

Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site
por: D'Annessa, Ilda, et al.
Publicado: (2014)

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
por: D'Annessa, Ilda, et al.
Publicado: (2012)

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
por: Fernandez-Prada, Christopher, et al.
Publicado: (2018)

Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
por: Tesauro, Cinzia, et al.
Publicado: (2013)

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach
por: Ibarra-Meneses, Ana Victoria, et al.
Publicado: (2022)

Thiophene derivatives activity against the protozoan parasite Leishmania infantum
por: Bigot, Sophia, et al.
Publicado: (2022)

Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery
por: Bhattacharya, Arijit, et al.
Publicado: (2020)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Proteomic and Genomic Analyses of Antimony Resistant Leishmania infantum Mutant
por: Brotherton, Marie-Christine, et al.
Publicado: (2013)

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2019)

Identification of asymptomatic Leishmania infections: a scoping review
por: Ibarra-Meneses, Ana Victoria, et al.
Publicado: (2022)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Peptides for Infectious Diseases: From Probe Design to Diagnostic Microarrays
por: Cretich, Marina, et al.
Publicado: (2019)

Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis
por: Monte-Neto, Rubens, et al.
Publicado: (2015)

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
por: Schellens, J. H., et al.
Publicado: (1996)

Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca(2+) pumps: A computational study
por: Di Marino, Daniele, et al.
Publicado: (2015)

Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum()
por: Potvin, Jade-Éva, et al.
Publicado: (2023)

Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis
por: do Monte-Neto, Rubens L., et al.
Publicado: (2011)

Oral and Intragastric: New Routes of Infection by Leishmania braziliensis and Leishmania infantum?
por: Reimann, Mayra M., et al.
Publicado: (2022)

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum
por: Gutiérrez-Corbo, Camino, et al.
Publicado: (2019)

Growth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice
por: Santi, Ana Maria Murta, et al.
Publicado: (2018)

Leishmania infantum in US-Born Dog
por: de Almeida, Marcos E., et al.
Publicado: (2020)

Toxicity and Anti-promastigote Activity of Benzoxazinoid Analogs Against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) infantum
por: de Sousa, Gilberto, et al.
Publicado: (2020)

Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites
por: Douanne, Noélie, et al.
Publicado: (2020)

T-cell activation, senescence, and exhaustion in asymptomatic HIV/Leishmania infantum co-infection
por: de Oliveira Mendes-Aguiar, Carolina, et al.
Publicado: (2023)

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species
por: Rochette, Annie, et al.
Publicado: (2008)

Vaccination with Leishmania infantum Acidic Ribosomal P0 but Not with Nucleosomal Histones Proteins Controls Leishmania infantum Infection in Hamsters
por: Pereira, Lais, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_q9hi4e85t02m0dk1hpr4h9irke