Cargando…

Untargeted Metabolomics Uncovers the Essential Lysine Transporter in Toxoplasma gondii

Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, and cryptosporidiosis. Current treatments are limited by emerging resistance to, as well as the high cost and toxicity of existing drugs. As obligate intracellular parasites, apicomplexans rely on the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kloehn, Joachim, Lunghi, Matteo, Varesio, Emmanuel, Dubois, David, Soldati-Favre, Dominique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399914/ https://www.ncbi.nlm.nih.gov/pubmed/34436417 http://dx.doi.org/10.3390/metabo11080476

Ejemplares similares

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
por: Lunghi, Matteo, et al.
Publicado: (2022)

A Signaling Factor Linked to Toxoplasma gondii Guanylate Cyclase Complex Controls Invasion and Egress during Acute and Chronic Infection
por: Ye, Shu, et al.
Publicado: (2022)

Ceramide biosynthesis is critical for establishment of the intracellular niche of Toxoplasma gondii
por: Nyonda, Mary Akinyi, et al.
Publicado: (2022)

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
por: Kloehn, Joachim, et al.
Publicado: (2020)

Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii
por: Tosetti, Nicolò, et al.
Publicado: (2020)

Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
por: Lentini, Gaëlle, et al.
Publicado: (2021)

Dual Targeting of Antioxidant and Metabolic Enzymes to the Mitochondrion and the Apicoplast of Toxoplasma gondii
por: Pino, Paco, et al.
Publicado: (2007)

Concerted Action of Two Formins in Gliding Motility and Host Cell Invasion by Toxoplasma gondii
por: Daher, Wassim, et al.
Publicado: (2010)

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii
por: Limenitakis, Julien, et al.
Publicado: (2013)

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis
por: Tymoshenko, Stepan, et al.
Publicado: (2015)

Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii
por: Boillat, Madlaina, et al.
Publicado: (2020)

Plasticity between MyoC- and MyoA-Glideosomes: An Example of Functional Compensation in Toxoplasma gondii Invasion
por: Frénal, Karine, et al.
Publicado: (2014)

Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress
por: Dubois, David J., et al.
Publicado: (2023)

Three F-actin assembly centers regulate organelle inheritance, cell-cell communication and motility in Toxoplasma gondii
por: Tosetti, Nicolò, et al.
Publicado: (2019)

Toxoplasma gondii phosphatidylserine flippase complex ATP2B-CDC50.4 critically participates in microneme exocytosis
por: Bisio, Hugo, et al.
Publicado: (2022)

Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex
por: Dos Santos Pacheco, Nicolas, et al.
Publicado: (2021)

Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii
por: Lodoen, Melissa B., et al.
Publicado: (2021)

The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells
por: Graindorge, Arnault, et al.
Publicado: (2016)

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii
por: Frénal, Karine, et al.
Publicado: (2017)

Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii
por: Nie, Lan-Bi, et al.
Publicado: (2020)

Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion
por: Frénal, Karine, et al.
Publicado: (2015)

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
por: Zhao, Wei, et al.
Publicado: (2022)

Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii
por: He, Kai, et al.
Publicado: (2023)

Identification and Characterization of an Escorter for Two Secretory Adhesins in Toxoplasma gondii
por: Reiss, Matthias, et al.
Publicado: (2001)

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii
por: Kumar, Amit, et al.
Publicado: (2023)

Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms
por: Andenmatten, Nicole, et al.
Publicado: (2012)

Role of Toxoplasma gondii Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance
por: Kannan, Geetha, et al.
Publicado: (2019)

Global Lysine Crotonylation and 2-Hydroxyisobutyrylation in Phenotypically Different Toxoplasma gondii Parasites
por: Yin, Deqi, et al.
Publicado: (2019)

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing
por: Wilkinson, Daniel J., et al.
Publicado: (2020)

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress
por: Dogga, Sunil Kumar, et al.
Publicado: (2017)

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection
por: Fox, Barbara A., et al.
Publicado: (2016)

Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation
por: Wang, Jiachen, et al.
Publicado: (2014)

ATF6β is a host cellular target of the Toxoplasma gondii virulence factor ROP18
por: Yamamoto, Masahiro, et al.
Publicado: (2011)

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei
por: Oppenheim, Rebecca D., et al.
Publicado: (2014)

The Motility of a Human Parasite, Toxoplasma gondii, Is Regulated by a Novel Lysine Methyltransferase
por: Heaslip, Aoife T., et al.
Publicado: (2011)

A Coccidia-Specific Phosphate Transporter Is Essential for the Growth of Toxoplasma gondii Parasites
por: Cui, Jianmin, et al.
Publicado: (2022)

Toxoplasma gondii
por: Liesenfeld, Oliver
Publicado: (2009)

Calcium Uptake and Proton Transport by Acidocalcisomes of Toxoplasma gondii
por: Rohloff, Peter, et al.
Publicado: (2011)

The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid
por: Bullen, Hayley E., et al.
Publicado: (2019)

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
por: Yamamoto, Masahiro, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_i31lni5bh5j3i1r2uo89qmrol4