Cargando…

Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study

Background: vitamin D (VD) may be a protective factor for retinoblastoma, though no temporal association has been reported during pregnancy or the child’s first year of life. Serum VD concentrations are determined by both distal (DF) and proximal factors (PF). Objective: To identify if DF and PF can...

Descripción completa

Detalles Bibliográficos
Autores principales: Mejía-Rodríguez, Fabiola, Flores-Aldana, Mario E., Quezada-Sánchez, Amado D., Shamah-Levy, Teresa, Villalpando, Salvador, Contreras-Manzano, Alejandra, Bhatt-Carreño, Silvia, Orjuela-Grimm, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399960/
https://www.ncbi.nlm.nih.gov/pubmed/34444670
http://dx.doi.org/10.3390/nu13082510
_version_ 1783745200352395264
author Mejía-Rodríguez, Fabiola
Flores-Aldana, Mario E.
Quezada-Sánchez, Amado D.
Shamah-Levy, Teresa
Villalpando, Salvador
Contreras-Manzano, Alejandra
Bhatt-Carreño, Silvia
Orjuela-Grimm, Manuela
author_facet Mejía-Rodríguez, Fabiola
Flores-Aldana, Mario E.
Quezada-Sánchez, Amado D.
Shamah-Levy, Teresa
Villalpando, Salvador
Contreras-Manzano, Alejandra
Bhatt-Carreño, Silvia
Orjuela-Grimm, Manuela
author_sort Mejía-Rodríguez, Fabiola
collection PubMed
description Background: vitamin D (VD) may be a protective factor for retinoblastoma, though no temporal association has been reported during pregnancy or the child’s first year of life. Serum VD concentrations are determined by both distal (DF) and proximal factors (PF). Objective: To identify if DF and PF can predict VD insufficiency (VDI) and VD deficiency (VDD) in women of childbearing age; and to test whether maternal exposure to DF and PF during pregnancy and a child’s exposure during the first 11.9 months postpartum are associated with sporadic retinoblastoma (SRb) in children. Methods: This is a secondary analysis of data from the Epidemiology of SRb in Mexico (EpiRbMx) study and the National Health and Nutrition Survey 2018–2019 (ENSANUT 2018–2019, for its acronym in Spanish). The association of DF and PF with VDD or VDI was estimated using ENSANUT 2018–2019, and the association of DF and PF with SRb using EpiRbMx. All were estimated using logistic regression, with comparable samples selected from ENSANUT 2018–2019 and EpiRbMx. Results: Altitude, latitude and obesity predicted VDI and VDD in ENSANUT women. In EpiRbMx, residence in a rural location during pregnancy increased the risk of SRb. For children, rural residence and latitude increased the risk of SRb, while the number of days exposed to the spring–summer season during months 6 to 11.9 of life was protective. Conclusions: risk of VDI and VDD in women (ENSANUT 2018–2019) increased with altitude, urban dwelling, overweight and obesity. The child and mother’s place of residence, including altitude, latitude and rural classification were important predictors of SRb in EpiRbMx.
format Online
Article
Text
id pubmed-8399960
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83999602021-08-29 Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study Mejía-Rodríguez, Fabiola Flores-Aldana, Mario E. Quezada-Sánchez, Amado D. Shamah-Levy, Teresa Villalpando, Salvador Contreras-Manzano, Alejandra Bhatt-Carreño, Silvia Orjuela-Grimm, Manuela Nutrients Article Background: vitamin D (VD) may be a protective factor for retinoblastoma, though no temporal association has been reported during pregnancy or the child’s first year of life. Serum VD concentrations are determined by both distal (DF) and proximal factors (PF). Objective: To identify if DF and PF can predict VD insufficiency (VDI) and VD deficiency (VDD) in women of childbearing age; and to test whether maternal exposure to DF and PF during pregnancy and a child’s exposure during the first 11.9 months postpartum are associated with sporadic retinoblastoma (SRb) in children. Methods: This is a secondary analysis of data from the Epidemiology of SRb in Mexico (EpiRbMx) study and the National Health and Nutrition Survey 2018–2019 (ENSANUT 2018–2019, for its acronym in Spanish). The association of DF and PF with VDD or VDI was estimated using ENSANUT 2018–2019, and the association of DF and PF with SRb using EpiRbMx. All were estimated using logistic regression, with comparable samples selected from ENSANUT 2018–2019 and EpiRbMx. Results: Altitude, latitude and obesity predicted VDI and VDD in ENSANUT women. In EpiRbMx, residence in a rural location during pregnancy increased the risk of SRb. For children, rural residence and latitude increased the risk of SRb, while the number of days exposed to the spring–summer season during months 6 to 11.9 of life was protective. Conclusions: risk of VDI and VDD in women (ENSANUT 2018–2019) increased with altitude, urban dwelling, overweight and obesity. The child and mother’s place of residence, including altitude, latitude and rural classification were important predictors of SRb in EpiRbMx. MDPI 2021-07-23 /pmc/articles/PMC8399960/ /pubmed/34444670 http://dx.doi.org/10.3390/nu13082510 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mejía-Rodríguez, Fabiola
Flores-Aldana, Mario E.
Quezada-Sánchez, Amado D.
Shamah-Levy, Teresa
Villalpando, Salvador
Contreras-Manzano, Alejandra
Bhatt-Carreño, Silvia
Orjuela-Grimm, Manuela
Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title_full Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title_fullStr Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title_full_unstemmed Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title_short Association between Predictors of Vitamin D Serum Levels and Risk of Retinoblastoma in Children: A Case-Control Study
title_sort association between predictors of vitamin d serum levels and risk of retinoblastoma in children: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399960/
https://www.ncbi.nlm.nih.gov/pubmed/34444670
http://dx.doi.org/10.3390/nu13082510
work_keys_str_mv AT mejiarodriguezfabiola associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT floresaldanamarioe associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT quezadasanchezamadod associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT shamahlevyteresa associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT villalpandosalvador associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT contrerasmanzanoalejandra associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT bhattcarrenosilvia associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy
AT orjuelagrimmmanuela associationbetweenpredictorsofvitamindserumlevelsandriskofretinoblastomainchildrenacasecontrolstudy