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Opioid-Associated Amnestic Syndrome

A 31-year-old male with a history significant for obesity, attention deficit hyperactivity disorder, methamphetamine use, and IV drug use was evaluated for unexplained global amnesia greater than 24 h. The patient had been in recovery for opioid use disorder for about a year, but he relapsed on IV f...

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Detalles Bibliográficos
Autores principales: Ciurylo, William, Noh, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399965/
https://www.ncbi.nlm.nih.gov/pubmed/34471572
http://dx.doi.org/10.7759/cureus.16714
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author Ciurylo, William
Noh, Elizabeth
author_facet Ciurylo, William
Noh, Elizabeth
author_sort Ciurylo, William
collection PubMed
description A 31-year-old male with a history significant for obesity, attention deficit hyperactivity disorder, methamphetamine use, and IV drug use was evaluated for unexplained global amnesia greater than 24 h. The patient had been in recovery for opioid use disorder for about a year, but he relapsed on IV fentanyl in the week prior to presentation. On exam, he was alert and fully oriented but had no spontaneous recall of three objects after five minutes. General medical and neurological examinations were otherwise unrevealing. Urine fentanyl and norfentanyl were positive. CT and MRI imaging demonstrated isolated bilateral hippocampal injury. Given the totality of his presentation and the contributing variables, his medical team considered this to be a case of the newly characterized opioid-associated amnestic syndrome (OAS). This case is significant because of the relative absence of potentially confounding variables on presentation, including antecedent cardiorespiratory failure. Further reporting of these cases may have implications for understanding opioid toxicity and clarifying the functional role of the hippocampus.
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spelling pubmed-83999652021-08-31 Opioid-Associated Amnestic Syndrome Ciurylo, William Noh, Elizabeth Cureus Internal Medicine A 31-year-old male with a history significant for obesity, attention deficit hyperactivity disorder, methamphetamine use, and IV drug use was evaluated for unexplained global amnesia greater than 24 h. The patient had been in recovery for opioid use disorder for about a year, but he relapsed on IV fentanyl in the week prior to presentation. On exam, he was alert and fully oriented but had no spontaneous recall of three objects after five minutes. General medical and neurological examinations were otherwise unrevealing. Urine fentanyl and norfentanyl were positive. CT and MRI imaging demonstrated isolated bilateral hippocampal injury. Given the totality of his presentation and the contributing variables, his medical team considered this to be a case of the newly characterized opioid-associated amnestic syndrome (OAS). This case is significant because of the relative absence of potentially confounding variables on presentation, including antecedent cardiorespiratory failure. Further reporting of these cases may have implications for understanding opioid toxicity and clarifying the functional role of the hippocampus. Cureus 2021-07-29 /pmc/articles/PMC8399965/ /pubmed/34471572 http://dx.doi.org/10.7759/cureus.16714 Text en Copyright © 2021, Ciurylo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ciurylo, William
Noh, Elizabeth
Opioid-Associated Amnestic Syndrome
title Opioid-Associated Amnestic Syndrome
title_full Opioid-Associated Amnestic Syndrome
title_fullStr Opioid-Associated Amnestic Syndrome
title_full_unstemmed Opioid-Associated Amnestic Syndrome
title_short Opioid-Associated Amnestic Syndrome
title_sort opioid-associated amnestic syndrome
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399965/
https://www.ncbi.nlm.nih.gov/pubmed/34471572
http://dx.doi.org/10.7759/cureus.16714
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