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Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis

Benign uterine disorders, including uterine fibroids (UF) and adenomyosis (AM), can impact the life quality and fertility of women of reproductive age. Transvaginal ultrasound (TVUS) has long been used for their early identification, but its combined use with elastography seems to improve diagnostic...

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Autores principales: Săsăran, Vladut, Turdean, Sabin, Gliga, Marius, Ilyes, Levente, Grama, Ovidiu, Muntean, Mihai, Pușcașiu, Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399978/
https://www.ncbi.nlm.nih.gov/pubmed/34442468
http://dx.doi.org/10.3390/jpm11080824
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author Săsăran, Vladut
Turdean, Sabin
Gliga, Marius
Ilyes, Levente
Grama, Ovidiu
Muntean, Mihai
Pușcașiu, Lucian
author_facet Săsăran, Vladut
Turdean, Sabin
Gliga, Marius
Ilyes, Levente
Grama, Ovidiu
Muntean, Mihai
Pușcașiu, Lucian
author_sort Săsăran, Vladut
collection PubMed
description Benign uterine disorders, including uterine fibroids (UF) and adenomyosis (AM), can impact the life quality and fertility of women of reproductive age. Transvaginal ultrasound (TVUS) has long been used for their early identification, but its combined use with elastography seems to improve diagnostic accuracy of UF and AM. Thus, a prospective pilot study was conducted on 79 patients who underwent hysterectomy (25 microscopically diagnosed with AM and 53 with UF), with the aim of assessing the ability of TVUS combined with strain ratio elastography (SE) to accurately diagnose and distinguish UF and AM. Significantly higher mean and maximal strain ratio (SR) values were identified for patients with histologically confirmed AM as opposed to those with UF (p < 0.001). Diagnostic sensitivity and specificity, calculated in comparison with histology results, were higher for UF than AM. Receiver operating characteristic (ROC) analysis was applied between the two study groups, revealing cutoff values of 7.71 for mean SR and 8.91 for maximal SR, respectively, with good sensitivity and specificity parameters (100% and 96.23%; 96% and 96.23%). Our results support the use of TVUS in combination with SE for the positive and differential diagnosis of UF and AM, through identification of their particular tissue stiffness features.
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spelling pubmed-83999782021-08-29 Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis Săsăran, Vladut Turdean, Sabin Gliga, Marius Ilyes, Levente Grama, Ovidiu Muntean, Mihai Pușcașiu, Lucian J Pers Med Article Benign uterine disorders, including uterine fibroids (UF) and adenomyosis (AM), can impact the life quality and fertility of women of reproductive age. Transvaginal ultrasound (TVUS) has long been used for their early identification, but its combined use with elastography seems to improve diagnostic accuracy of UF and AM. Thus, a prospective pilot study was conducted on 79 patients who underwent hysterectomy (25 microscopically diagnosed with AM and 53 with UF), with the aim of assessing the ability of TVUS combined with strain ratio elastography (SE) to accurately diagnose and distinguish UF and AM. Significantly higher mean and maximal strain ratio (SR) values were identified for patients with histologically confirmed AM as opposed to those with UF (p < 0.001). Diagnostic sensitivity and specificity, calculated in comparison with histology results, were higher for UF than AM. Receiver operating characteristic (ROC) analysis was applied between the two study groups, revealing cutoff values of 7.71 for mean SR and 8.91 for maximal SR, respectively, with good sensitivity and specificity parameters (100% and 96.23%; 96% and 96.23%). Our results support the use of TVUS in combination with SE for the positive and differential diagnosis of UF and AM, through identification of their particular tissue stiffness features. MDPI 2021-08-23 /pmc/articles/PMC8399978/ /pubmed/34442468 http://dx.doi.org/10.3390/jpm11080824 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Săsăran, Vladut
Turdean, Sabin
Gliga, Marius
Ilyes, Levente
Grama, Ovidiu
Muntean, Mihai
Pușcașiu, Lucian
Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title_full Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title_fullStr Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title_full_unstemmed Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title_short Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
title_sort value of strain-ratio elastography in the diagnosis and differentiation of uterine fibroids and adenomyosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399978/
https://www.ncbi.nlm.nih.gov/pubmed/34442468
http://dx.doi.org/10.3390/jpm11080824
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