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Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review
A new coronavirus disease (COVID-19) has already affected millions of people in 213 countries. The possibilities of treatment have been reviewed in recent publications but there are many controversial results and conclusions. An analysis of the studies did not reveal a difference in mortality level...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400016/ https://www.ncbi.nlm.nih.gov/pubmed/34440497 http://dx.doi.org/10.3390/life11080753 |
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author | Starshinova, Anna Malkova, Anna Zinchenko, Ulia Kudlay, Dmitry Glushkova, Anzhela Dovgalyk, Irina Yablonskiy, Piotr Shoenfeld, Yehuda |
author_facet | Starshinova, Anna Malkova, Anna Zinchenko, Ulia Kudlay, Dmitry Glushkova, Anzhela Dovgalyk, Irina Yablonskiy, Piotr Shoenfeld, Yehuda |
author_sort | Starshinova, Anna |
collection | PubMed |
description | A new coronavirus disease (COVID-19) has already affected millions of people in 213 countries. The possibilities of treatment have been reviewed in recent publications but there are many controversial results and conclusions. An analysis of the studies did not reveal a difference in mortality level between people treated with standard therapy, such as antiviral drugs and dexamethasone, and new antiviral drugs/additional immune therapy. However, most studies describe clinical improvement and a decrease in mortality among patients with severe and critical conditions, with the early initiation of additional immune therapy. Possible new targets based on viral life cycles were considered. Unfortunately, the data analysis on the efficacy of different medicine and therapy regimens among patients with COVID-19, showed little success in decreasing the mortality rate in all treatment methods. Some efficacy has been shown with an immunosuppressive therapy in small patient samples, but when a larger number of patients were analyzed the data did not differ significantly from the control groups. |
format | Online Article Text |
id | pubmed-8400016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84000162021-08-29 Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review Starshinova, Anna Malkova, Anna Zinchenko, Ulia Kudlay, Dmitry Glushkova, Anzhela Dovgalyk, Irina Yablonskiy, Piotr Shoenfeld, Yehuda Life (Basel) Review A new coronavirus disease (COVID-19) has already affected millions of people in 213 countries. The possibilities of treatment have been reviewed in recent publications but there are many controversial results and conclusions. An analysis of the studies did not reveal a difference in mortality level between people treated with standard therapy, such as antiviral drugs and dexamethasone, and new antiviral drugs/additional immune therapy. However, most studies describe clinical improvement and a decrease in mortality among patients with severe and critical conditions, with the early initiation of additional immune therapy. Possible new targets based on viral life cycles were considered. Unfortunately, the data analysis on the efficacy of different medicine and therapy regimens among patients with COVID-19, showed little success in decreasing the mortality rate in all treatment methods. Some efficacy has been shown with an immunosuppressive therapy in small patient samples, but when a larger number of patients were analyzed the data did not differ significantly from the control groups. MDPI 2021-07-27 /pmc/articles/PMC8400016/ /pubmed/34440497 http://dx.doi.org/10.3390/life11080753 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Starshinova, Anna Malkova, Anna Zinchenko, Ulia Kudlay, Dmitry Glushkova, Anzhela Dovgalyk, Irina Yablonskiy, Piotr Shoenfeld, Yehuda Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title | Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title_full | Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title_fullStr | Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title_full_unstemmed | Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title_short | Efficacy of Different Types of Therapy for COVID-19: A Comprehensive Review |
title_sort | efficacy of different types of therapy for covid-19: a comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400016/ https://www.ncbi.nlm.nih.gov/pubmed/34440497 http://dx.doi.org/10.3390/life11080753 |
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