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Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature
We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400025/ https://www.ncbi.nlm.nih.gov/pubmed/34436437 http://dx.doi.org/10.3390/metabo11080496 |
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author | Boebinger, Scott E. Brothers, Rowan O. Bong, Sistania Sanders, Bharat McCracken, Courtney Ting, Lena H. Buckley, Erin M. |
author_facet | Boebinger, Scott E. Brothers, Rowan O. Bong, Sistania Sanders, Bharat McCracken, Courtney Ting, Lena H. Buckley, Erin M. |
author_sort | Boebinger, Scott E. |
collection | PubMed |
description | We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO(2VO) and VO(2AO), respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO(2i)). Despite the lack of previous validation, VO(2i) is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO(2i) with VO(2VO) and VO(2AO) in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO(2i), VO(2VO), and VO(2AO) were excellent. VO(2i) was not significantly correlated with VO(2AO) (p = 0.15) nor VO(2VO) (p = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO(2i) and VO(2AO)/VO(2VO) in the MG is substantial across participants. Thus, it is preferable to calibrate VO(2i) prior to every monitoring session. Important future work is needed to compare VO(2i) against gold standard modalities such as positron emission tomography or magnetic resonance imaging. |
format | Online Article Text |
id | pubmed-8400025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84000252021-08-29 Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature Boebinger, Scott E. Brothers, Rowan O. Bong, Sistania Sanders, Bharat McCracken, Courtney Ting, Lena H. Buckley, Erin M. Metabolites Article We lack reliable methods to continuously assess localized, resting-state muscle activity that are comparable across individuals. Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial occlusions (VO(2VO) and VO(2AO), respectively). However, this technique is not suitable for continuous monitoring, and its utility is limited to those who can tolerate occlusions. Combining NIRS with diffuse correlated spectroscopy (DCS) enables continuous measurement of an index of muscle oxygen metabolism (VO(2i)). Despite the lack of previous validation, VO(2i) is employed as a measure of oxygen metabolism in the muscle. Here we characterized measurement repeatability and compared VO(2i) with VO(2VO) and VO(2AO) in the medial gastrocnemius (MG) in 9 healthy adults. Intra-participant repeatability of VO(2i), VO(2VO), and VO(2AO) were excellent. VO(2i) was not significantly correlated with VO(2AO) (p = 0.15) nor VO(2VO) (p = 0.55). This lack of correlation suggests that the variability in the calibration coefficient between VO(2i) and VO(2AO)/VO(2VO) in the MG is substantial across participants. Thus, it is preferable to calibrate VO(2i) prior to every monitoring session. Important future work is needed to compare VO(2i) against gold standard modalities such as positron emission tomography or magnetic resonance imaging. MDPI 2021-07-29 /pmc/articles/PMC8400025/ /pubmed/34436437 http://dx.doi.org/10.3390/metabo11080496 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boebinger, Scott E. Brothers, Rowan O. Bong, Sistania Sanders, Bharat McCracken, Courtney Ting, Lena H. Buckley, Erin M. Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title_full | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title_fullStr | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title_full_unstemmed | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title_short | Diffuse Optical Spectroscopy Assessment of Resting Oxygen Metabolism in the Leg Musculature |
title_sort | diffuse optical spectroscopy assessment of resting oxygen metabolism in the leg musculature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400025/ https://www.ncbi.nlm.nih.gov/pubmed/34436437 http://dx.doi.org/10.3390/metabo11080496 |
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