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Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicro...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400034/ https://www.ncbi.nlm.nih.gov/pubmed/34443822 http://dx.doi.org/10.3390/nano11081991 |
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author | Bengalli, Rossella Fiandra, Luisa Vineis, Claudia Sanchez-Ramirez, Diego Omar Azoia, Nuno G. Varesano, Alessio Mantecca, Paride |
author_facet | Bengalli, Rossella Fiandra, Luisa Vineis, Claudia Sanchez-Ramirez, Diego Omar Azoia, Nuno G. Varesano, Alessio Mantecca, Paride |
author_sort | Bengalli, Rossella |
collection | PubMed |
description | Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicrobial properties. The functional properties of the materials were verified, and their safety was evaluated. Two main exposure scenarios for humans were identified: inhalation of PPy NPs during spray (manufacturing) and direct skin contact with NPs-coated fabrics (use). Thus, the toxicity properties of PPy NPs and PPy-coated textiles were assessed by using in vitro models representative of the lung and the skin. The results from the materials’ characterization showed the stability of both the PPy NP suspension and the textile coating, even after washing cycles and extraction in artificial sweat. Data from an in vitro model of the air–blood barrier showed the low toxicity of these NPs, with no alteration of cell viability and functionality observed. The skin toxicity of PPy NPs and the coated textiles was assessed on a reconstructed human epidermis model following OECD 431 and 439 guidelines. PPy NPs proved to be non-corrosive at the tested conditions, as well as non-irritant after extraction in artificial sweat at two different pH conditions. The obtained data suggest that PPy NPs are safe NMs in applications for textile coating. |
format | Online Article Text |
id | pubmed-8400034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84000342021-08-29 Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles Bengalli, Rossella Fiandra, Luisa Vineis, Claudia Sanchez-Ramirez, Diego Omar Azoia, Nuno G. Varesano, Alessio Mantecca, Paride Nanomaterials (Basel) Article Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicrobial properties. The functional properties of the materials were verified, and their safety was evaluated. Two main exposure scenarios for humans were identified: inhalation of PPy NPs during spray (manufacturing) and direct skin contact with NPs-coated fabrics (use). Thus, the toxicity properties of PPy NPs and PPy-coated textiles were assessed by using in vitro models representative of the lung and the skin. The results from the materials’ characterization showed the stability of both the PPy NP suspension and the textile coating, even after washing cycles and extraction in artificial sweat. Data from an in vitro model of the air–blood barrier showed the low toxicity of these NPs, with no alteration of cell viability and functionality observed. The skin toxicity of PPy NPs and the coated textiles was assessed on a reconstructed human epidermis model following OECD 431 and 439 guidelines. PPy NPs proved to be non-corrosive at the tested conditions, as well as non-irritant after extraction in artificial sweat at two different pH conditions. The obtained data suggest that PPy NPs are safe NMs in applications for textile coating. MDPI 2021-08-03 /pmc/articles/PMC8400034/ /pubmed/34443822 http://dx.doi.org/10.3390/nano11081991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bengalli, Rossella Fiandra, Luisa Vineis, Claudia Sanchez-Ramirez, Diego Omar Azoia, Nuno G. Varesano, Alessio Mantecca, Paride Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title | Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title_full | Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title_fullStr | Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title_full_unstemmed | Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title_short | Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles |
title_sort | safety assessment of polypyrrole nanoparticles and spray-coated textiles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400034/ https://www.ncbi.nlm.nih.gov/pubmed/34443822 http://dx.doi.org/10.3390/nano11081991 |
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