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Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles

Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicro...

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Autores principales: Bengalli, Rossella, Fiandra, Luisa, Vineis, Claudia, Sanchez-Ramirez, Diego Omar, Azoia, Nuno G., Varesano, Alessio, Mantecca, Paride
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400034/
https://www.ncbi.nlm.nih.gov/pubmed/34443822
http://dx.doi.org/10.3390/nano11081991
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author Bengalli, Rossella
Fiandra, Luisa
Vineis, Claudia
Sanchez-Ramirez, Diego Omar
Azoia, Nuno G.
Varesano, Alessio
Mantecca, Paride
author_facet Bengalli, Rossella
Fiandra, Luisa
Vineis, Claudia
Sanchez-Ramirez, Diego Omar
Azoia, Nuno G.
Varesano, Alessio
Mantecca, Paride
author_sort Bengalli, Rossella
collection PubMed
description Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicrobial properties. The functional properties of the materials were verified, and their safety was evaluated. Two main exposure scenarios for humans were identified: inhalation of PPy NPs during spray (manufacturing) and direct skin contact with NPs-coated fabrics (use). Thus, the toxicity properties of PPy NPs and PPy-coated textiles were assessed by using in vitro models representative of the lung and the skin. The results from the materials’ characterization showed the stability of both the PPy NP suspension and the textile coating, even after washing cycles and extraction in artificial sweat. Data from an in vitro model of the air–blood barrier showed the low toxicity of these NPs, with no alteration of cell viability and functionality observed. The skin toxicity of PPy NPs and the coated textiles was assessed on a reconstructed human epidermis model following OECD 431 and 439 guidelines. PPy NPs proved to be non-corrosive at the tested conditions, as well as non-irritant after extraction in artificial sweat at two different pH conditions. The obtained data suggest that PPy NPs are safe NMs in applications for textile coating.
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spelling pubmed-84000342021-08-29 Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles Bengalli, Rossella Fiandra, Luisa Vineis, Claudia Sanchez-Ramirez, Diego Omar Azoia, Nuno G. Varesano, Alessio Mantecca, Paride Nanomaterials (Basel) Article Polypyrrole (PPy) nanoparticles (NPs) are used for the coating of materials, such as textiles, with biomedical applications, including wound care and tissue engineering, but they are also promising antibacterial agents. In this work, PPy NPs were used for the spray-coating of textiles with antimicrobial properties. The functional properties of the materials were verified, and their safety was evaluated. Two main exposure scenarios for humans were identified: inhalation of PPy NPs during spray (manufacturing) and direct skin contact with NPs-coated fabrics (use). Thus, the toxicity properties of PPy NPs and PPy-coated textiles were assessed by using in vitro models representative of the lung and the skin. The results from the materials’ characterization showed the stability of both the PPy NP suspension and the textile coating, even after washing cycles and extraction in artificial sweat. Data from an in vitro model of the air–blood barrier showed the low toxicity of these NPs, with no alteration of cell viability and functionality observed. The skin toxicity of PPy NPs and the coated textiles was assessed on a reconstructed human epidermis model following OECD 431 and 439 guidelines. PPy NPs proved to be non-corrosive at the tested conditions, as well as non-irritant after extraction in artificial sweat at two different pH conditions. The obtained data suggest that PPy NPs are safe NMs in applications for textile coating. MDPI 2021-08-03 /pmc/articles/PMC8400034/ /pubmed/34443822 http://dx.doi.org/10.3390/nano11081991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bengalli, Rossella
Fiandra, Luisa
Vineis, Claudia
Sanchez-Ramirez, Diego Omar
Azoia, Nuno G.
Varesano, Alessio
Mantecca, Paride
Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title_full Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title_fullStr Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title_full_unstemmed Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title_short Safety Assessment of Polypyrrole Nanoparticles and Spray-Coated Textiles
title_sort safety assessment of polypyrrole nanoparticles and spray-coated textiles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400034/
https://www.ncbi.nlm.nih.gov/pubmed/34443822
http://dx.doi.org/10.3390/nano11081991
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