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Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores

DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selectivity of GyrB...

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Detalles Bibliográficos
Autores principales:	Tomašič, Tihomir, Zubrienė, Asta, Skok, Žiga, Martini, Riccardo, Pajk, Stane, Sosič, Izidor, Ilaš, Janez, Matulis, Daumantas, Bryant, Sharon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400042/ https://www.ncbi.nlm.nih.gov/pubmed/34451886 http://dx.doi.org/10.3390/ph14080789

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