Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents. Several Hsp90 N-terminal domain inhibitors have been evaluated in clinical trials, but none have been approved as...

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Detalles Bibliográficos
Autores principales: Dernovšek, Jaka, Zajec, Živa, Durcik, Martina, Mašič, Lucija Peterlin, Gobec, Martina, Zidar, Nace, Tomašič, Tihomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400049/
https://www.ncbi.nlm.nih.gov/pubmed/34452244
http://dx.doi.org/10.3390/pharmaceutics13081283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400049/
https://www.ncbi.nlm.nih.gov/pubmed/34452244
http://dx.doi.org/10.3390/pharmaceutics13081283

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