Cargando…
High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors
Background. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reac...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400111/ https://www.ncbi.nlm.nih.gov/pubmed/34440486 http://dx.doi.org/10.3390/life11080742 |
_version_ | 1783745237353496576 |
---|---|
author | Koziarska-Rościszewska, Małgorzata Gluba-Brzózka, Anna Franczyk, Beata Rysz, Jacek |
author_facet | Koziarska-Rościszewska, Małgorzata Gluba-Brzózka, Anna Franczyk, Beata Rysz, Jacek |
author_sort | Koziarska-Rościszewska, Małgorzata |
collection | PubMed |
description | Background. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reactive protein (hsCRP) with selected factors—age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D-25(OH)D, cardiovascular diseases (CVD), coronary heart disease, cerebrovascular disease, and hypertension. Results. Statistically significant correlations were found between hsCRP and the following: age (rs = 0.304, p = 0.0000); gender (female) (p = 0.0173); BMI (rs = 0.295, p = 0.0001); waist circumference (rs = 0.250, p = 0.0007); dyslipidemia (p = 0.0159); glycemia (rs = 0.173, p = 0.0207); and significant negative correlations between hsCRP and 25(OH)D (rs = −0.203, p = 0.0065). In patients with CVD, hypertension, diabetes, or visceral obesity, hsCRP was significantly higher than in the subgroup without these disorders. There was a statistically significant relationship between hsCRP and the number of the metabolic syndrome elements (p = 0.0053). Conclusions. The hsCRP test seem to be a simple test that may be used at the primary care level to identify patients at risk of metabolic disorders, CVD, and hypertension. Vitamin D concentration may be a determining factor of systemic inflammation (it may have a modulating effect). |
format | Online Article Text |
id | pubmed-8400111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84001112021-08-29 High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors Koziarska-Rościszewska, Małgorzata Gluba-Brzózka, Anna Franczyk, Beata Rysz, Jacek Life (Basel) Article Background. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reactive protein (hsCRP) with selected factors—age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D-25(OH)D, cardiovascular diseases (CVD), coronary heart disease, cerebrovascular disease, and hypertension. Results. Statistically significant correlations were found between hsCRP and the following: age (rs = 0.304, p = 0.0000); gender (female) (p = 0.0173); BMI (rs = 0.295, p = 0.0001); waist circumference (rs = 0.250, p = 0.0007); dyslipidemia (p = 0.0159); glycemia (rs = 0.173, p = 0.0207); and significant negative correlations between hsCRP and 25(OH)D (rs = −0.203, p = 0.0065). In patients with CVD, hypertension, diabetes, or visceral obesity, hsCRP was significantly higher than in the subgroup without these disorders. There was a statistically significant relationship between hsCRP and the number of the metabolic syndrome elements (p = 0.0053). Conclusions. The hsCRP test seem to be a simple test that may be used at the primary care level to identify patients at risk of metabolic disorders, CVD, and hypertension. Vitamin D concentration may be a determining factor of systemic inflammation (it may have a modulating effect). MDPI 2021-07-26 /pmc/articles/PMC8400111/ /pubmed/34440486 http://dx.doi.org/10.3390/life11080742 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Koziarska-Rościszewska, Małgorzata Gluba-Brzózka, Anna Franczyk, Beata Rysz, Jacek High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title_full | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title_fullStr | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title_full_unstemmed | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title_short | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
title_sort | high-sensitivity c-reactive protein relationship with metabolic disorders and cardiovascular diseases risk factors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400111/ https://www.ncbi.nlm.nih.gov/pubmed/34440486 http://dx.doi.org/10.3390/life11080742 |
work_keys_str_mv | AT koziarskarosciszewskamałgorzata highsensitivitycreactiveproteinrelationshipwithmetabolicdisordersandcardiovasculardiseasesriskfactors AT glubabrzozkaanna highsensitivitycreactiveproteinrelationshipwithmetabolicdisordersandcardiovasculardiseasesriskfactors AT franczykbeata highsensitivitycreactiveproteinrelationshipwithmetabolicdisordersandcardiovasculardiseasesriskfactors AT ryszjacek highsensitivitycreactiveproteinrelationshipwithmetabolicdisordersandcardiovasculardiseasesriskfactors |