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In Vitro Evaluation of Poly(lactide-co-glycolide) In Situ Forming Gels for Bedaquiline Fumarate Salt and Pharmacokinetics Following Subcutaneous Injection in Rats

This study evaluated in vitro and in vivo drug release of bedaquiline from in situ forming gels (ISGs) containing 200 mg eq./g bedaquiline fumarate salt prepared with four different grades of poly(d,l-lactide) (PDLLA) or poly(d,l-lactide-co-glycolide) (PLGA) with a lactide/glycolide ratio of 50/50 o...

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Detalles Bibliográficos
Autores principales:	Van Hemelryck, Sandy, Wens, Rani, van Poppel, Hannelore, Luijks, Milou, Shahidi, Koosha, Marczak, Marcin, Kahnt, Ariane, Holm, René, Mannaert, Erik, Langguth, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400137/ https://www.ncbi.nlm.nih.gov/pubmed/34452192 http://dx.doi.org/10.3390/pharmaceutics13081231

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