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Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) partic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400156/ https://www.ncbi.nlm.nih.gov/pubmed/34444668 http://dx.doi.org/10.3390/nu13082508 |
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author | Pourhassan, Maryam Babel, Nina Sieske, Lars Westhoff, Timm Henning Wirth, Rainer |
author_facet | Pourhassan, Maryam Babel, Nina Sieske, Lars Westhoff, Timm Henning Wirth, Rainer |
author_sort | Pourhassan, Maryam |
collection | PubMed |
description | There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition. |
format | Online Article Text |
id | pubmed-8400156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84001562021-08-29 Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients Pourhassan, Maryam Babel, Nina Sieske, Lars Westhoff, Timm Henning Wirth, Rainer Nutrients Article There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition. MDPI 2021-07-22 /pmc/articles/PMC8400156/ /pubmed/34444668 http://dx.doi.org/10.3390/nu13082508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pourhassan, Maryam Babel, Nina Sieske, Lars Westhoff, Timm Henning Wirth, Rainer Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title_full | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title_fullStr | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title_full_unstemmed | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title_short | Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients |
title_sort | longitudinal changes of cytokines and appetite in older hospitalized patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400156/ https://www.ncbi.nlm.nih.gov/pubmed/34444668 http://dx.doi.org/10.3390/nu13082508 |
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