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Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients

There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) partic...

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Autores principales: Pourhassan, Maryam, Babel, Nina, Sieske, Lars, Westhoff, Timm Henning, Wirth, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400156/
https://www.ncbi.nlm.nih.gov/pubmed/34444668
http://dx.doi.org/10.3390/nu13082508
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author Pourhassan, Maryam
Babel, Nina
Sieske, Lars
Westhoff, Timm Henning
Wirth, Rainer
author_facet Pourhassan, Maryam
Babel, Nina
Sieske, Lars
Westhoff, Timm Henning
Wirth, Rainer
author_sort Pourhassan, Maryam
collection PubMed
description There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition.
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spelling pubmed-84001562021-08-29 Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients Pourhassan, Maryam Babel, Nina Sieske, Lars Westhoff, Timm Henning Wirth, Rainer Nutrients Article There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition. MDPI 2021-07-22 /pmc/articles/PMC8400156/ /pubmed/34444668 http://dx.doi.org/10.3390/nu13082508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pourhassan, Maryam
Babel, Nina
Sieske, Lars
Westhoff, Timm Henning
Wirth, Rainer
Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title_full Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title_fullStr Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title_full_unstemmed Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title_short Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients
title_sort longitudinal changes of cytokines and appetite in older hospitalized patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400156/
https://www.ncbi.nlm.nih.gov/pubmed/34444668
http://dx.doi.org/10.3390/nu13082508
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