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Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400162/ https://www.ncbi.nlm.nih.gov/pubmed/34442765 http://dx.doi.org/10.3390/microorganisms9081686 |
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author | Sililas, Palin Huang, Lingling Thonusin, Chanisa Luewan, Suchaya Chattipakorn, Nipon Chattipakorn, Siriporn Tongsong, Theera |
author_facet | Sililas, Palin Huang, Lingling Thonusin, Chanisa Luewan, Suchaya Chattipakorn, Nipon Chattipakorn, Siriporn Tongsong, Theera |
author_sort | Sililas, Palin |
collection | PubMed |
description | Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed. |
format | Online Article Text |
id | pubmed-8400162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84001622021-08-29 Association between Gut Microbiota and Development of Gestational Diabetes Mellitus Sililas, Palin Huang, Lingling Thonusin, Chanisa Luewan, Suchaya Chattipakorn, Nipon Chattipakorn, Siriporn Tongsong, Theera Microorganisms Article Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed. MDPI 2021-08-08 /pmc/articles/PMC8400162/ /pubmed/34442765 http://dx.doi.org/10.3390/microorganisms9081686 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sililas, Palin Huang, Lingling Thonusin, Chanisa Luewan, Suchaya Chattipakorn, Nipon Chattipakorn, Siriporn Tongsong, Theera Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title | Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title_full | Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title_fullStr | Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title_full_unstemmed | Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title_short | Association between Gut Microbiota and Development of Gestational Diabetes Mellitus |
title_sort | association between gut microbiota and development of gestational diabetes mellitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400162/ https://www.ncbi.nlm.nih.gov/pubmed/34442765 http://dx.doi.org/10.3390/microorganisms9081686 |
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