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Association between Gut Microbiota and Development of Gestational Diabetes Mellitus

Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary...

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Autores principales: Sililas, Palin, Huang, Lingling, Thonusin, Chanisa, Luewan, Suchaya, Chattipakorn, Nipon, Chattipakorn, Siriporn, Tongsong, Theera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400162/
https://www.ncbi.nlm.nih.gov/pubmed/34442765
http://dx.doi.org/10.3390/microorganisms9081686
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author Sililas, Palin
Huang, Lingling
Thonusin, Chanisa
Luewan, Suchaya
Chattipakorn, Nipon
Chattipakorn, Siriporn
Tongsong, Theera
author_facet Sililas, Palin
Huang, Lingling
Thonusin, Chanisa
Luewan, Suchaya
Chattipakorn, Nipon
Chattipakorn, Siriporn
Tongsong, Theera
author_sort Sililas, Palin
collection PubMed
description Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed.
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spelling pubmed-84001622021-08-29 Association between Gut Microbiota and Development of Gestational Diabetes Mellitus Sililas, Palin Huang, Lingling Thonusin, Chanisa Luewan, Suchaya Chattipakorn, Nipon Chattipakorn, Siriporn Tongsong, Theera Microorganisms Article Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed. MDPI 2021-08-08 /pmc/articles/PMC8400162/ /pubmed/34442765 http://dx.doi.org/10.3390/microorganisms9081686 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sililas, Palin
Huang, Lingling
Thonusin, Chanisa
Luewan, Suchaya
Chattipakorn, Nipon
Chattipakorn, Siriporn
Tongsong, Theera
Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title_full Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title_fullStr Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title_full_unstemmed Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title_short Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
title_sort association between gut microbiota and development of gestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400162/
https://www.ncbi.nlm.nih.gov/pubmed/34442765
http://dx.doi.org/10.3390/microorganisms9081686
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