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Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into

Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human–computer interaction. However, the mechanical properties mismatch between the electrode material and the brain...

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Detalles Bibliográficos
Autores principales: Hao, Zhiyan, Wang, Sen, Zhang, Kun, Zhou, Jiajia, Li, Dichen, He, Jiankang, Gao, Lin, Wang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400188/
https://www.ncbi.nlm.nih.gov/pubmed/34443240
http://dx.doi.org/10.3390/ma14164718
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author Hao, Zhiyan
Wang, Sen
Zhang, Kun
Zhou, Jiajia
Li, Dichen
He, Jiankang
Gao, Lin
Wang, Ling
author_facet Hao, Zhiyan
Wang, Sen
Zhang, Kun
Zhou, Jiajia
Li, Dichen
He, Jiankang
Gao, Lin
Wang, Ling
author_sort Hao, Zhiyan
collection PubMed
description Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human–computer interaction. However, the mechanical properties mismatch between the electrode material and the brain tissue seriously affects the stability of electrode signal acquisition and the effectiveness of long-term service in vivo. In this study, a modified neuroelectrode was developed with conductive biomaterials. The electrode has good biocompatibility and a gradient microstructure suitable for cell growth. Compared with metal electrodes, bioelectrodes not only greatly reduced the elastic modulus (<10 kpa) but also increased the conductivity of the electrode by 200 times. Through acute electrophysiological analysis and a 12-week chronic in vivo experiment, the bioelectrode clearly recorded the rat’s brain electrical signals, effectively avoided the generation of glial scars and induced neurons to move closer to the electrode. The new conductive biomaterial electrodes developed in this research make long-term implantation of cortical nerve electrodes possible.
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spelling pubmed-84001882021-08-29 Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into Hao, Zhiyan Wang, Sen Zhang, Kun Zhou, Jiajia Li, Dichen He, Jiankang Gao, Lin Wang, Ling Materials (Basel) Article Implantable nerve electrodes, as a bridge between the brain and external devices, have been widely used in areas such as brain function exploration, neurological disease treatment and human–computer interaction. However, the mechanical properties mismatch between the electrode material and the brain tissue seriously affects the stability of electrode signal acquisition and the effectiveness of long-term service in vivo. In this study, a modified neuroelectrode was developed with conductive biomaterials. The electrode has good biocompatibility and a gradient microstructure suitable for cell growth. Compared with metal electrodes, bioelectrodes not only greatly reduced the elastic modulus (<10 kpa) but also increased the conductivity of the electrode by 200 times. Through acute electrophysiological analysis and a 12-week chronic in vivo experiment, the bioelectrode clearly recorded the rat’s brain electrical signals, effectively avoided the generation of glial scars and induced neurons to move closer to the electrode. The new conductive biomaterial electrodes developed in this research make long-term implantation of cortical nerve electrodes possible. MDPI 2021-08-21 /pmc/articles/PMC8400188/ /pubmed/34443240 http://dx.doi.org/10.3390/ma14164718 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hao, Zhiyan
Wang, Sen
Zhang, Kun
Zhou, Jiajia
Li, Dichen
He, Jiankang
Gao, Lin
Wang, Ling
Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title_full Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title_fullStr Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title_full_unstemmed Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title_short Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into
title_sort biofabrication of a low modulus bioelectroprobe for neurons to grow into
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400188/
https://www.ncbi.nlm.nih.gov/pubmed/34443240
http://dx.doi.org/10.3390/ma14164718
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