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Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms

Background and Objectives: Helicobacter pylori (H. pylori) infection impairs quality of life. However, whether eradication therapy ameliorates gastrointestinal symptoms remains questionable. The main objective of this study was to evaluate the influence of H. pylori eradication therapy on gastrointe...

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Autores principales: Mestrovic, Antonio, Bozic, Josko, Vukojevic, Katarina, Tonkic, Ante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400225/
https://www.ncbi.nlm.nih.gov/pubmed/34441009
http://dx.doi.org/10.3390/medicina57080803
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author Mestrovic, Antonio
Bozic, Josko
Vukojevic, Katarina
Tonkic, Ante
author_facet Mestrovic, Antonio
Bozic, Josko
Vukojevic, Katarina
Tonkic, Ante
author_sort Mestrovic, Antonio
collection PubMed
description Background and Objectives: Helicobacter pylori (H. pylori) infection impairs quality of life. However, whether eradication therapy ameliorates gastrointestinal symptoms remains questionable. The main objective of this study was to evaluate the influence of H. pylori eradication therapy on gastrointestinal symptoms. Materials and Methods: A total of 140 patients, 59 women and 81 men, with a mean age of 61 and suffering from H. pylori infection in the University Hospital of Split, Croatia, were enrolled in the study. Patients were randomly assigned to either concomitant or hybrid therapies. The Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was completed by patients prior to and after the eradication therapy. Results: In both groups, the total GSRS score improved significantly after therapy. In the concomitant group, the abdominal pain score, reflux symptoms score and indigestion score decreased significantly after therapy. In the group with hybrid therapy, all five groups of symptoms (abdominal pain, reflux symptoms, indigestion, diarrhea and constipation) significantly decreased after therapy. Patients with adverse events had significantly higher total GSRS scores after eradication therapy. Conclusions: H. pylori eradication therapy could alleviate gastrointestinal symptoms regardless of the treatment used, but the favorable effect seemed to be more pronounced after hybrid therapy.
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spelling pubmed-84002252021-08-29 Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms Mestrovic, Antonio Bozic, Josko Vukojevic, Katarina Tonkic, Ante Medicina (Kaunas) Article Background and Objectives: Helicobacter pylori (H. pylori) infection impairs quality of life. However, whether eradication therapy ameliorates gastrointestinal symptoms remains questionable. The main objective of this study was to evaluate the influence of H. pylori eradication therapy on gastrointestinal symptoms. Materials and Methods: A total of 140 patients, 59 women and 81 men, with a mean age of 61 and suffering from H. pylori infection in the University Hospital of Split, Croatia, were enrolled in the study. Patients were randomly assigned to either concomitant or hybrid therapies. The Gastrointestinal Symptom Rating Scale (GSRS) questionnaire was completed by patients prior to and after the eradication therapy. Results: In both groups, the total GSRS score improved significantly after therapy. In the concomitant group, the abdominal pain score, reflux symptoms score and indigestion score decreased significantly after therapy. In the group with hybrid therapy, all five groups of symptoms (abdominal pain, reflux symptoms, indigestion, diarrhea and constipation) significantly decreased after therapy. Patients with adverse events had significantly higher total GSRS scores after eradication therapy. Conclusions: H. pylori eradication therapy could alleviate gastrointestinal symptoms regardless of the treatment used, but the favorable effect seemed to be more pronounced after hybrid therapy. MDPI 2021-08-05 /pmc/articles/PMC8400225/ /pubmed/34441009 http://dx.doi.org/10.3390/medicina57080803 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mestrovic, Antonio
Bozic, Josko
Vukojevic, Katarina
Tonkic, Ante
Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title_full Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title_fullStr Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title_full_unstemmed Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title_short Impact of Different Helicobacter pylori Eradication Therapies on Gastrointestinal Symptoms
title_sort impact of different helicobacter pylori eradication therapies on gastrointestinal symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400225/
https://www.ncbi.nlm.nih.gov/pubmed/34441009
http://dx.doi.org/10.3390/medicina57080803
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